Journal article
Effects of time-restricted eating in early-stage Huntington's disease: a pilot study
Nature metabolism
09/17/2026
DOI: 10.1038/s42255-026-01612-x
PMID: 42754730
Abstract
Time-restricted eating (TRE) has shown neuroprotective potential in preclinical models of Huntington's disease (HD) but has not been tested clinically. Here, we report the results of a 12-week open-label pilot trial ( NCT06490367 ) of 8-h TRE, alongside standard-of-care diet and activity recommendations, in 20 individuals with early-stage HD. We show that TRE is feasible, well tolerated and associated with favourable changes in clinical measures of HD and plasma neurofilament light levels. Overall, these results support the need for further investigation of TRE as a potential lifestyle intervention in HD.
Details
- Title: Subtitle
- Effects of time-restricted eating in early-stage Huntington's disease: a pilot study
- Creators
- Russell G Wells - Oregon Health & Science UniversityLee E Neilson - University of IowaAndrew W McHill - Oregon Health & Science UniversityNora E Gray - Oregon Health & Science UniversityJoseph F Quinn - Oregon Health & Science UniversityAmie L Hiller - Oregon Health & Science University
- Resource Type
- Journal article
- Publication Details
- Nature metabolism
- DOI
- 10.1038/s42255-026-01612-x
- PMID
- 42754730
- NLM abbreviation
- Nat Metab
- ISSN
- 2522-5812
- eISSN
- 2522-5812
- Publisher
- Nature
- Grant note
- VA CSR&D CDA2 IK2 CX00253 / U.S. Department of Veterans Affairs (Department of Veterans Affairs)
- Language
- English
- Electronic publication date
- 09/17/2026
- Academic Unit
- Neurology
- Record Identifier
- 9985230781802771
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