Effects of total body irradiation and cyclosporin a on the lethality of toxic shock syndrome toxin-1 in a rabbit model of toxic shock syndrome

Martin M Dinges; Dale S Gregerson; Timothy J Tripp; John K McCormick; Patrick M Schlievert

doi:10.1086/378514

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Effects of total body irradiation and cyclosporin a on the lethality of toxic shock syndrome toxin-1 in a rabbit model of toxic shock syndrome

Journal article

Open access

Peer reviewed

Effects of total body irradiation and cyclosporin a on the lethality of toxic shock syndrome toxin-1 in a rabbit model of toxic shock syndrome

Martin M Dinges, Dale S Gregerson, Timothy J Tripp, John K McCormick and Patrick M Schlievert

The Journal of infectious diseases, Vol.188(8), pp.1142-1145

10/15/2003

DOI: 10.1086/378514

PMID: 14551884

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Abstract

Toxic shock syndrome (TSS) may be mediated by superantigen-activated T cells, a theory we tested in rabbits, which are more susceptible to the lethal effects of superantigens, such as TSS toxin-1 (TSST-1), than are mice. Rabbits exposed to 10 cGy of total body irradiation exhibited T cell deficiency, with profound depletion of splenic lymphocytes and circulating CD4(+) lymphocytes, as well as an inability to manifest delayed-type hypersensitivity. Nevertheless, these rabbits remained completely susceptible to TSST-1, indicating that TSS can occur in the setting of marked immunosuppression.

Enterotoxins - radiation effects

Superantigens - toxicity

Rabbits

Whole-Body Irradiation

Enterotoxins - toxicity

Staphylococcal Infections - immunology

T-Lymphocytes

Cyclosporine - pharmacology

Shock, Septic - immunology

Shock, Septic - mortality

Staphylococcus aureus - pathogenicity

Shock, Septic - microbiology

Staphylococcal Infections - mortality

Immunosuppression

Animals

Superantigens - radiation effects

Bacterial Toxins

Female

Mice

Mice, Inbred BALB C

Staphylococcal Infections - microbiology

Immunosuppressive Agents - pharmacology

Staphylococcus aureus - metabolism

Details

Title: Subtitle: Effects of total body irradiation and cyclosporin a on the lethality of toxic shock syndrome toxin-1 in a rabbit model of toxic shock syndrome
Creators: Martin M Dinges - Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Dale S Gregerson
Timothy J Tripp
John K McCormick
Patrick M Schlievert
Resource Type: Journal article
Publication Details: The Journal of infectious diseases, Vol.188(8), pp.1142-1145
Publisher: United States
DOI: 10.1086/378514
PMID: 14551884
ISSN: 0022-1899
eISSN: 1537-6613
Grant note: AI22159 / NIAID NIH HHS
Language: English
Date published: 10/15/2003
Academic Unit: Microbiology and Immunology; Internal Medicine
Record Identifier: 9984001136402771

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