Journal article
Effects of transcranial magnetic stimulation on the human brain recorded with intracranial electrocorticography
Molecular psychiatry, Vol.29(5), pp.1228-1240
05/2024
DOI: 10.1038/s41380-024-02405-y
PMCID: PMC12574714
PMID: 38317012
Abstract
Transcranial magnetic stimulation (TMS) is increasingly used as a noninvasive technique for neuromodulation in research and clinical applications, yet its mechanisms are not well understood. Here, we present the neurophysiological effects of TMS using intracranial electrocorticography (iEEG) in neurosurgical patients. We first evaluated safety in a gel-based phantom. We then performed TMS-iEEG in 22 neurosurgical participants with no adverse events. We next evaluated intracranial responses to single pulses of TMS to the dorsolateral prefrontal cortex (dlPFC) (N = 10, 1414 electrodes). We demonstrate that TMS is capable of inducing evoked potentials both locally within the dlPFC and in downstream regions functionally connected to the dlPFC, including the anterior cingulate and insular cortex. These downstream effects were not observed when stimulating other distant brain regions. Intracranial dlPFC electrical stimulation had similar timing and downstream effects as TMS. These findings support the safety and promise of TMS-iEEG in humans to examine local and network-level effects of TMS with higher spatiotemporal resolution than currently available methods.
Details
- Title: Subtitle
- Effects of transcranial magnetic stimulation on the human brain recorded with intracranial electrocorticography
- Creators
- Jeffrey B Wang - Stanford MedicineUmair Hassan - Stanford UniversityJoel E Bruss - University of IowaHiroyuki Oya - Department of Neurosurgery, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USABrandt D Uitermarkt - University of IowaNicholas T Trapp - University of IowaPhillip E Gander - Department of Radiology, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USAMatthew A Howard III - Department of Neurosurgery, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USACorey J Keller - Stanford UniversityAaron D Boes - Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, 52242, USA. aaron-boes@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Molecular psychiatry, Vol.29(5), pp.1228-1240
- DOI
- 10.1038/s41380-024-02405-y
- PMID
- 38317012
- PMCID
- PMC12574714
- NLM abbreviation
- Mol Psychiatry
- ISSN
- 1359-4184
- eISSN
- 1476-5578
- Grant note
- 4 R01NS114405 / U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 5T32-MH019113 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) F30MH119763 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R21MH120441 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) 1R01 MH132074 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH129018 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
- Language
- English
- Electronic publication date
- 02/05/2024
- Date published
- 05/2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Psychiatry; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics); Neurosurgery; Otolaryngology; Health, Sport, and Human Physiology
- Record Identifier
- 9984557858702771
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