Journal article
Effects of two prototypic polychlorinated biphenyls (PCBs) on lipid composition of rat liver and serum
The Journal of nutritional biochemistry, Vol.1(7), pp.350-354
1990
DOI: 10.1016/0955-2863(90)90002-3
PMID: 15539224
Abstract
Mature male Sprague-Dawley rats received a single IP injection of either 2,2′,4,4′,5,5′-hexachlorobiphenyl (HCB), 3,3′,4,4′-tetrachlorobiphenyl (TCB) (300 μm/kg) in corn oil (10 ml/kg) or the corn oil vehicle alone, and were killed four days later after having been fasted overnight. The vehicle control group consisted of rats which were allowed free access to feed as well as pair-fed animals. Lipid analyses were conducted on liver, hepatic microsomes and serum. TCB- (but no HCB-) treatment resulted in a statistically significant increase in total liver lipids and triglycerides. Liver phospholipids remained unchanged. Both PCBs increased the cholestrol and phospholipids content of the liver microsomal fraction. Serum lipids measured were not statistically different from control values. While HCB had little effect on the fatty acid composition of liver lipids, TCB caused an increase in C 18:1 (n-9) and a decrease in C 20:4 (n-6). Both PCBs increased C 18:0 in the hepatic microsomal fraction, but TCB also decreased C 16:0. Neither PCB altered the fatty acid composition of serum total lipids. These data are consistent with the concept that specific alterations in lipid metabolism are dependent on the structure of the PCB.
Details
- Title: Subtitle
- Effects of two prototypic polychlorinated biphenyls (PCBs) on lipid composition of rat liver and serum
- Creators
- Véronique Azaïs-Braesco - Laboratoire des Sciences de la Consommation, I.N.R.A.—Centre de Recherches de Jouy, Jouy-en-Josas, FranceJean-Paul Macaire - Laboratoire des Sciences de la Consommation, I.N.R.A.—Centre de Recherches de Jouy, Jouy-en-Josas, FrancePaul Bellenand - Laboratoire des Sciences de la Consommation, I.N.R.A.—Centre de Recherches de Jouy, Jouy-en-Josas, FranceLarry W Robertson - Graduate Center for Toxicology, University of Kentucky, Lexington, KY, USAGérard Pascal - Laboratoire des Sciences de la Consommation, I.N.R.A.—Centre de Recherches de Jouy, Jouy-en-Josas, France
- Resource Type
- Journal article
- Publication Details
- The Journal of nutritional biochemistry, Vol.1(7), pp.350-354
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0955-2863(90)90002-3
- PMID
- 15539224
- ISSN
- 0955-2863
- eISSN
- 1873-4847
- Language
- English
- Date published
- 1990
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984002406902771
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