Journal article
Effects of vasodilator stimuli on resistance of large and small cerebral vessels
The American journal of physiology, Vol.251(6 Pt 2), pp.H1176-H1182
12/1986
DOI: 10.1152/ajpheart.1986.251.6.H1176
PMID: 3789170
Abstract
We have examined effects of vasodilator stimuli on segmental resistance in the cerebral circulation. Our hypothesis was that resistance of large arteries, as well as small vessels, contributes to cerebral vascular responses to vasodilator stimuli. We measured cerebral blood flow with microspheres in anesthetized rabbits and measured pressure in pial arteries approximately 100 microns diameter using a servo-null method. These values were used to calculate resistance of large arteries (greater than 100 microns diameter) and small vessels (less than 100 microns diameter). Under control conditions, resistance of large arteries accounted for one-third to one-half of total cerebral vascular resistance. Intracarotid infusion of acetylcholine (1 microgram/min) reduced large arterial resistance by 69% and small vessel resistance by 58%. Adenosine also produced marked reductions in resistance of both large and small cerebral vessels. In contrast, seizures reduced large arterial resistance by 50% and small vessel resistance by 85%. Pial arterial pressure, which depends on the ratio of large and small vessel resistance, increased during infusion of acetylcholine and adenosine, but decreased during seizures. We conclude that both large and small cerebral vessels are responsive to acetylcholine and adenosine, and seizures produce preferential reduction in resistance of small vessels.
Details
- Title: Subtitle
- Effects of vasodilator stimuli on resistance of large and small cerebral vessels
- Creators
- Kinya TamakiWilliam MayhanDonald Heistad
- Resource Type
- Journal article
- Publication Details
- The American journal of physiology, Vol.251(6 Pt 2), pp.H1176-H1182
- DOI
- 10.1152/ajpheart.1986.251.6.H1176
- PMID
- 3789170
- NLM abbreviation
- Am J Physiol
- ISSN
- 0002-9513
- eISSN
- 2163-5773
- Publisher
- United States
- Grant note
- HL-16066 / NHLBI NIH HHS HL-14388 / NHLBI NIH HHS HL-14230 / NHLBI NIH HHS
- Language
- English
- Date published
- 12/1986
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040213202771
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