Journal article
Effects of vessel geometry and catheter position on dose delivery in intracoronary brachytherapy
IEEE transactions on biomedical engineering, Vol.50(11), pp.1286-1295
2003
DOI: 10.1109/TBME.2003.818474
PMID: 14619999
Abstract
In-stent restenosis is commonly observed in coronary arteries after intervention. Intravascular brachytherapy has been found effective in reducing the recurrence of restenosis after stent placement. Conventional dosing models for brachytherapy with beta (/spl beta/) radiation neglect vessel geometry as well as the position of the delivery catheter. This paper demonstrates in computer simulations on phantoms and on in vivo patient data that the estimated dose distribution varies substantially in curved vessels. In simulated phantoms of 50-mm length with a shape corresponding to a 60/spl deg/-180/spl deg/ segment of a respectively sized torus, the average dose in 2-mm depth was decreased by 2.70%-7.48% at the outer curvature and increased by 2.95%-9.70% at the inner curvature as compared with a straight phantom. In vivo data were represented in a geometrically correct three-dimensional model that was derived by fusion of intravascular ultrasound (IVUS) and biplane angiography. These data were compared with a simplified tubular model reflecting common assumptions of conventional dosing schemes. The simplified model yielded significantly lower estimates of the delivered radiation and the dose variability as compared with a geometrically correct model (p < 0.001). The estimated dose in ten vessel segments of eight patients was on average 8.76% lower at the lumen/plaque and 6.52% lower at the media/adventitia interfaces (simplified tubular model relative to geometrically correct model). The differences in dose estimates between the two models were significantly higher in the right coronary artery as compared with the left coronary artery (p < 0.001).
Details
- Title: Subtitle
- Effects of vessel geometry and catheter position on dose delivery in intracoronary brachytherapy
- Creators
- Andreas WAHLE - Department of Electrical and Computer Engineering, 3320 Seamans Center for Engineering, University of Iowa, Iowa City, IA 52242, United StatesJohn J LOPEZ - University of Chicago, Department of Medicine, Chicago, IL 60637, United StatesEdward C PENNINGTON - Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, United StatesSanford L MEEKS - Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, United StatesKathleen C BRADDY - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, United StatesJames M FOX - Grand Traverse Heart Associates, Traverse City, MI 49684, United StatesTheresa M. H BRENNAN - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, United StatesJohn M BUATTI - Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, United StatesJames D ROSSEN - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, United StatesMilan SONKA - Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- IEEE transactions on biomedical engineering, Vol.50(11), pp.1286-1295
- DOI
- 10.1109/TBME.2003.818474
- PMID
- 14619999
- NLM abbreviation
- IEEE Trans Biomed Eng
- ISSN
- 0018-9294
- eISSN
- 1558-2531
- Publisher
- Institute of Electrical and Electronics Engineers; New York, NY
- Language
- English
- Date published
- 2003
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Electrical and Computer Engineering; Cardiovascular Medicine; Radiation Oncology; Injury Prevention Research Center; Neurosurgery; Otolaryngology; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984020874202771
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