Efferent mechanisms mediating renal sodium and water excretion induced by centrally administered serotonin

Rosa Montes; Alan Kim Johnson

doi:10.1152/ajpregu.1990.259.6.r1267

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Efferent mechanisms mediating renal sodium and water excretion induced by centrally administered serotonin

Journal article

Peer reviewed

Efferent mechanisms mediating renal sodium and water excretion induced by centrally administered serotonin

Rosa Montes and Alan Kim Johnson

The American journal of physiology, Vol.259(6 Pt 2), pp.R1267-1273

12/1990

DOI: 10.1152/ajpregu.1990.259.6.r1267

PMID: 2148061

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Abstract

Treatments that increase central extracellular serotonin (5-HT) also increase Na excretion. Efferent renal sympathetic nerve activity (ERSNA) contributes to the control of Na and water reabsorption. To determine whether renal nerves play a role in the 5-HT-induced natriuresis, we examined the effect of intracerebroventricular (icv) injection of vehicle or 5-HT (20 micrograms) on Na, K, and urine excretion rates, as well as mean arterial pressure and heart rate in unanesthetized, hydrated rats with renal nerves intact or sectioned. Renal denervation attenuated the natriuresis produced by 5-HT but not the antidiuresis observed 15-30 min after injection. Central 5-HT produced brief pressor and bradycardic responses, followed by continued bradycardia and hypotension, which were more pronounced in intact rats. In other experiments, circulating levels of arginine vasopressin (AVP) and plasma atrial natriuretic polypeptide (ANP) were measured 15 min after icv injection of 5-HT. 5-HT significantly increased circulating AVP, but plasma ANP remained unchanged. These results suggest that renal nerves participate in the natriuresis elicited by centrally administered 5-HT through a decrease in ERSNA. The antidiuresis observed after central 5-HT may be due to an increase in AVP release.

Animals

Arginine Vasopressin - blood

Atrial Natriuretic Factor - blood

Brain - physiology

Cardiovascular Physiological Phenomena

Denervation

Diuresis - physiology

Efferent Pathways - physiology

Injections, Intraventricular

Kidney - innervation

Kidney - metabolism

Male

Natriuresis - physiology

Rats

Serotonin - pharmacology

Sympathetic Nervous System - physiology

Details

Title: Subtitle: Efferent mechanisms mediating renal sodium and water excretion induced by centrally administered serotonin
Creators: Rosa Montes - Department of Psychology, University of Iowa, Iowa City 52242
Alan Kim Johnson
Resource Type: Journal article
Publication Details: The American journal of physiology, Vol.259(6 Pt 2), pp.R1267-1273
DOI: 10.1152/ajpregu.1990.259.6.r1267
PMID: 2148061
NLM abbreviation: Am J Physiol
ISSN: 0002-9513
eISSN: 2163-5773
Grant note: HL-14388 / NHLBI NIH HHS
Language: English
Date published: 12/1990
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
Record Identifier: 9984213430902771

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