Efferent pathways of the coronary chemoreflex

A L Voigts; A L Mark; J Johannsen; P G Schmid; D D Heistad; F M Abboud

Back

Efferent pathways of the coronary chemoreflex

Journal article

Peer reviewed

Efferent pathways of the coronary chemoreflex

A L Voigts, A L Mark, J Johannsen, P G Schmid, D D Heistad and F M Abboud

The Journal of laboratory and clinical medicine, Vol.85(6), pp.898-903

06/1975

PMID: 1138023

View Online

Abstract

This study was performed to identify the efferent pathways which mediate vasodilation during activation of the coronary chemoreflex and to compare the reflex responses in vessels in skeletal muscle and skin. Reflex vasodilator responses (decreases in perfusion pressure) were measured in innervated, perfused gracilis muscle and hindpaw of dogs during activation of the coronary chemoreflex with intracoronary injections of nicotine. Reflex vasodilator responses to intracoronary nicotine (1.25 and 2.50 mu-g per kilogram) averaged -14 plus or minus 5 (S.E.M.) and -34 plus or minus 6 mm. Hg, respectively, in muscle, but only -5 plus or minus 2 and -10 plus or minus 4 mm. Hg, respectively, in paw. Atropine, tripelennamine, and propranolol did not alter the vasodilation. Guanethidine blocked reflex vasodilation in muscle. The reflex vasodilator responses in paw were slight and were not significantly attenuated by guanethidine. The results indicate that sympathetic cholinergic pathways to skeletal muscle do not participate in the coronary chemoreflex. The reflex vasodilation in muscle results from withdrawal of adrenergic constrictor tone. The efferent pathway demonstrates that the coronary chemoreflex does not produce striking withdrawal of adrenergic tone in paw. The results indicate, therefore, that activation of the coronary chemoreflex results in greater withdrawal of adrenergic constrictor tone and greater vasodilation in muscle than in skin.

Coronary Vessels - drug effects

Nicotine - administration & dosage

Vasodilator Agents - pharmacology

Vasomotor System - drug effects

Reflex - drug effects

Atropine - pharmacology

Cardiovascular System - drug effects

Hypotension - chemically induced

Nicotine - pharmacology

Skin - blood supply

Propranolol - pharmacology

Animals

Hindlimb - blood supply

Dogs

Muscles - blood supply

Guanethidine - pharmacology

Tripelennamine - pharmacology

Details

Title: Subtitle: Efferent pathways of the coronary chemoreflex
Creators: A L Voigts
A L Mark
J Johannsen
P G Schmid
D D Heistad
F M Abboud
Resource Type: Journal article
Publication Details: The Journal of laboratory and clinical medicine, Vol.85(6), pp.898-903
PMID: 1138023
NLM abbreviation: J Lab Clin Med
ISSN: 0022-2143
eISSN: 1532-6543
Publisher: Elsevier; United States
Language: English
Date published: 06/1975
Academic Unit: Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984025592502771

Metrics

16 Record Views

3 Times Cited - Web of Science