Journal article
Efficacy and safety of ezetimibe and ezetimibe plus statin therapy in patients aged under 65, 65–74 and 75 years and older
Aging health, Vol.3(6), pp.691-705
12/2007
DOI: 10.2217/1745509X.3.6.691
Abstract
Although the greatest burden of cardiovascular disease occurs after age 65 years, limited efficacy and safety data are available for cholesterol-lowering drugs in elderly patients. We undertook a pooled analysis of individual data from 13,282 patients aged 18–93 years in 16 published trials of ezetimibe and ezetimibe added on to or coadministered with a statin (ezetimibe/statin). Overall, ezetimibe reduced low-density lipoprotein cholesterol by 20% compared with placebo and ezetimibe/statin reduced low-density lipoprotein cholesterol by 17% compared with a statin alone, with consistent treatment effects across age groups (<65, 65–74 and ≥75 years). Rates of any adverse or drug-related adverse events were also similar across age groups. We conclude that the lipid efficacy and safety of ezetimibe and ezetimibe/statin in those aged 65–74 and 75 years and older are similar to those observed in patients aged under 65 years.
Details
- Title: Subtitle
- Efficacy and safety of ezetimibe and ezetimibe plus statin therapy in patients aged under 65, 65–74 and 75 years and older
- Creators
- Jennifer G Robinson - University of IowaMichael H Davidson - University of IowaArvind Shah - University of IowaJianxin Lin - University of Iowa, Departments of Epidemiology and Medicine, 200 Hawkins Drive SE 226 GH, Iowa City, IA 52242, USADavid Neff - University of IowaPaul T DeLucca - University of IowaJoanne E Tomassini - University of IowaEnrico Veltri - University of IowaAndrew M Tershakovec - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Aging health, Vol.3(6), pp.691-705
- DOI
- 10.2217/1745509X.3.6.691
- ISSN
- 1745-509X
- eISSN
- 1745-5103
- Language
- English
- Date published
- 12/2007
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984364453802771
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