Journal article
Efficacy of an artificial tear emulsion in patients with dry eye associated with meibomian gland dysfunction
Clinical Ophthalmology, Vol.7, pp.1713-1722
2013
DOI: 10.2147/OPTH.S35833
PMCID: PMC3770344
PMID: 24039391
Abstract
OBJECTIVES: The aim of the study reported here was to assess the efficacy of an artificial tear emulsion for the treatment of dry eye associated with meibomian gland dysfunction (MGD).METHODS: At five clinics, patients completed a 1-week treatment with their habitual topical therapy and then a 4-week treatment with open-label study medication: Systane® Balance Lubricant Eye Drops (Alcon, Alcon Inc, Fort Worth, TX, USA). Subjective assessments included a preference survey, the Impact of Dry Eye in Everyday Life questionnaire, and the Work Productivity and Activity Impairment questionnaire. Objective assessments by unmasked investigators included visual acuity, meibomian gland expression and dropout, tear film breakup time, corneal staining, and dosing frequency.RESULTS: At baseline, the 49 patients had mean meibomian gland expression grades and gland dropout that indicated mild to moderate MGD. Patients administered their habitual therapy 2.5 ± 1.3 times per day. After 4 weeks of study medication, the Impact of Dry Eye in Everyday Life questionnaire results indicated statistically and clinically significant improvements. Fewer than half of the participants were employed, limiting the usefulness of the Work Productivity and Activity Impairment questionnaire. Visual acuity remained statistically similar, while corneal staining and tear film breakup time improved significantly (P < 0.05) but modestly. The outcomes were achieved with 1.9 ± 1.1 doses per day of study medication, a significantly lower frequency than the habitual frequency (P < 0.001). The most common medication-related adverse event was blurred vision (3/49 patients, 6.1%). At study conclusion, 27/44 (61.4%) survey respondents preferred the study medication to their habitual therapy.CONCLUSION: The artificial tear emulsion was effective for treating the signs and symptoms of dry eye in MGD patients.
Details
- Title: Subtitle
- Efficacy of an artificial tear emulsion in patients with dry eye associated with meibomian gland dysfunction
- Creators
- Christine W SindtGary N Foulks
- Resource Type
- Journal article
- Publication Details
- Clinical Ophthalmology, Vol.7, pp.1713-1722
- DOI
- 10.2147/OPTH.S35833
- PMID
- 24039391
- PMCID
- PMC3770344
- NLM abbreviation
- Clin Ophthalmol
- ISSN
- 1177-5483
- eISSN
- 1177-5483
- Language
- English
- Date published
- 2013
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9983980091702771
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