Journal article
Efficacy of felbamate in a cohort of patients with Epilepsy with Myoclonic Atonic Seizures (EMAtS)
Epilepsy research, Vol.201, 107314
03/2024
DOI: 10.1016/j.eplepsyres.2024.107314
Abstract
Epilepsy with myoclonic atonic seizures (EMAtS) is a rare childhood onset developmental and epileptic encephalopathy which is frequently refractory to medical therapy. The optimal antiseizure medication remains unknown. This study reports the efficacy of felbamate in children with EMAtS. Six large pediatric epilepsy centers performed a retrospective chart review on patients diagnosed with EMAtS at their institutions and collected data on felbamate usage and efficacy. Responders were classified as patients who had a 50% or greater reduction in seizures with a given therapy. Out of 259 patients, 37 (14%) were treated with felbamate. The efficacy of felbamate was 62%, which was greater than that of either levetiracetam or valproic acid (15%, p < 0.001 and 32%, p = 0.001 respectively) and similar to that of the ketogenic diet (69%, p = 0.8). Felbamate appears to be an effective treatment for EMAtS and should be strongly considered in the treatment course of this disease.
•Seizures in EMAtS are often drug-resistant, however felbamate is rarely used.•Felbamate is more effective than either levetiracetam or valproic acid in EMAtS.•The efficacy of felbamate in EMAtS is similar to that of the ketogenic diet.
Details
- Title: Subtitle
- Efficacy of felbamate in a cohort of patients with Epilepsy with Myoclonic Atonic Seizures (EMAtS)
- Creators
- Laurel Reed - C. S. Mott Children's HospitalMichael Ciliberto - University of IowaSusan L Fong - Cincinnati Children's Hospital Medical CenterKatherine Nickels - Mayo ClinicEric Kossoff - Johns Hopkins HospitalElaine Wirrell - Mayo ClinicCharuta Joshi - The University of Texas Southwestern Medical Center
- Resource Type
- Journal article
- Publication Details
- Epilepsy research, Vol.201, 107314
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.eplepsyres.2024.107314
- ISSN
- 0920-1211
- eISSN
- 1872-6844
- Language
- English
- Electronic publication date
- 02/02/2024
- Date published
- 03/2024
- Academic Unit
- Stead Family Department of Pediatrics; Neurology; Neurology (Pediatrics)
- Record Identifier
- 9984557860202771
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