Journal article
Efficacy of obidoxime in human organophosphorus poisoning: Determination by neuromuscular transmission studies
Muscle & nerve, Vol.18(1), pp.15-22
01/1995
DOI: 10.1002/mus.880180104
PMID: 7799993
Abstract
Six patients with organophosphorus compound intoxications developed an intermediate syndrome (weakness and fasciculations) and obidoxime was given on eight occasions. The efficacy of the acetylcholinesterase (AChE) reactivator was monitored electrophysiologically by neuromuscular transmission studies using single and repetitive nerve stimulation (20 and 50 Hz) and the activity of the serum (butyryl) cholinesterase (ChE). Dramatic electrophysiologic improvement was seen when obidoxime was given early within 12 h in 3 patients, although evidence of AChE inhibition did not subside completely. When administration of obidoxime was delayed 26 h or more after intoxication on five occasions, electrophysiologic improvement was mild or absent. In one case, 66 h after intoxication with oxydemeton‐S‐methyl, the neuromuscular block worsened, indicating that aging of the AChE had been completed. The electrophysiologic improvement was always accompanied with better motor function but not necessarily with improvement of the overall clinical status. Serum ChE did not predict the oxime effect at the motor endplate. In humans, the efficacy of oximes in AChE reactivation can be determined rapidly using electrophysiologic studies.© 1995 John Wiley &Sons, Inc.
Details
- Title: Subtitle
- Efficacy of obidoxime in human organophosphorus poisoning: Determination by neuromuscular transmission studies
- Creators
- Roland BesserLudwig S WeilemannLudwig Gutmann
- Resource Type
- Journal article
- Publication Details
- Muscle & nerve, Vol.18(1), pp.15-22
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company; Hoboken
- DOI
- 10.1002/mus.880180104
- PMID
- 7799993
- ISSN
- 0148-639X
- eISSN
- 1097-4598
- Number of pages
- 8
- Language
- English
- Date published
- 01/1995
- Academic Unit
- Neurology
- Record Identifier
- 9984020653002771
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