Efficacy of sodium thiosulfate for the treatment for calciphylaxis

L Noureddine; M Landis; N Patel; S M Moe

doi:10.5414/CNP75485

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Efficacy of sodium thiosulfate for the treatment for calciphylaxis

Journal article

Peer reviewed

Efficacy of sodium thiosulfate for the treatment for calciphylaxis

L Noureddine, M Landis, N Patel and S M Moe

Clinical nephrology, Vol.75(6), pp.485-490

06/2011

DOI: 10.5414/CNP75485

PMID: 21612750

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Abstract

Calciphylaxis is a rare condition with dismal prognosis that affects patients with ESRD. Sodium thiosulfate (STS) may play a therapeutic role but its proposed efficacy is based on case reports and thus subject to publication bias. We identified all patients who received STS for any indication over a 5-year period through pharmacy records of 4 hospitals, retrospectively reviewing medical records for risk factors, laboratory values, the response of skin lesions to STS, and mortality. 14 patients received STS for calciphylaxis over 5 years. Following STS administration, pain decreased in 71% of patients, and 70% had an improvement in their lesions. Those who did not improve or stabilize their skin lesions tended to have more advanced skin lesions, were on renal replacement therapy longer, were more obese and received less total dose of STS. However, despite STS, there was a 71% mortality rate, with 50% of subjects dying within 6 months. We conclude in this study of all subjects who received STS at our Institution that STS is an effective treatment for the pain and skin lesions of calciphylaxis if given in the early stages of disease and for a consistent period of time. However, there is little impact on overall mortality compared to historical published cohorts.

Thiosulfates - therapeutic use

Calciphylaxis - drug therapy

Calciphylaxis - mortality

Humans

Middle Aged

Risk Factors

Renal Replacement Therapy

Male

Survival Rate

Treatment Outcome

Statistics, Nonparametric

Adult

Female

Aged

Retrospective Studies

Pain Measurement

Chelating Agents - therapeutic use

Details

Title: Subtitle: Efficacy of sodium thiosulfate for the treatment for calciphylaxis
Creators: L Noureddine - Division of Nephrology, Indiana University, University School of Medicine, Indianapolis, IN 46202, USA
M Landis
N Patel
S M Moe
Resource Type: Journal article
Publication Details: Clinical nephrology, Vol.75(6), pp.485-490
DOI: 10.5414/CNP75485
PMID: 21612750
ISSN: 0301-0430
Grant note: DK002775 / NIDDK NIH HHS
Language: English
Date published: 06/2011
Academic Unit: Nephrology; Internal Medicine
Record Identifier: 9984094615502771

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