Journal article
Efficacy of the HPV-16/18 AS04-Adjuvanted Vaccine Against Low-Risk HPV Types (PATRICIA Randomized Trial): An Unexpected Observation
The Journal of infectious diseases, Vol.208(9), pp.1391-1396
11/01/2013
DOI: 10.1093/infdis/jit360
PMCID: PMC3789574
PMID: 24092907
Abstract
Background.
Public Health England has reported a decrease of up to 20.8% in new diagnoses of external genital warts (GWs) among women aged <19 years since the national vaccination program with the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine began in 2008. A post hoc analysis of the phase III PATRICIA (PApilloma TRIal against Cancer In young Adults) trial (NCT00122681) was performed to ascertain whether protection against low-risk HPV types was apparent.
Methods.
Vaccine efficacy (VE) at 48 months was assessed against 6-month persistent infection (6MPI) with low-risk HPV types in the total vaccinated cohort (TVC) and in the TVC naive (for 25 HPV types tested) populations.
Results.
In the TVC naive cohort, VE against 6MPI (95% confidence interval) was 34.5% (11.3 to 51.8) for HPV-6/11, 34.9% (9.1 to 53.7) for HPV-6, 30.3% (−45.0 to 67.5) for HPV-11, and 49.5% (21.0 to 68.3) for HPV-74.
Conclusions.
The HPV-16/18 AS04-adjuvanted vaccine appears to have moderate efficacy against persistent infections with a number of low-risk HPV types (HPV-6/11/74), which are responsible for the majority of external GWs, and recently, antibody and cell-mediated immune response to HPV-6/11 have been observed. These findings may help to explain the decrease in external GW diagnoses seen in England.
Details
- Title: Subtitle
- Efficacy of the HPV-16/18 AS04-Adjuvanted Vaccine Against Low-Risk HPV Types (PATRICIA Randomized Trial): An Unexpected Observation
- Creators
- Anne Szarewski - Wolfson Institute of Preventive Medicine, Queen Mary University of LondonS. Rachel Skinner - Sydney University Discipline of Paediatrics and Child Health, Childrens Hospital WestmeadSuzanne M Garland - The Royal Women's HospitalBarbara Romanowski - University of AlbertaTino F Schwarz - Academic Teaching Hospital of the University of WuerzburgDan Apter - ,Song-Nan Chow - College of Medicine and the HospitalJorma Paavonen - University of HelsinkiM. Rowena Del Rosario-Raymundo - Barangay San Rafael, Maharlika Hi-wayJulio C Teixeira - University of CampinasNewton S De Carvalho - Federal University of Paraná, Infectious Diseases in Gynecology and Obstetrics SectorMaria Castro-Sanchez - Hospital Universitario Puerta de Hierro MajadahondaXavier Castellsagué - Institut Català d'Oncologia, L'Hospitalet de LlobregatWilly A. J Poppe - University Hospital KU Leuven GasthuisbergPhilippe De Sutter - University Hospital BrusselsWarner Huh - University of Alabama at BirminghamArchana Chatterjee - Creighton UniversityWiebren A Tjalma - Antwerp University Hospital, University of AntwerpenRonald T AckermanMark Martens - Jersey Shore University Medical CenterKim A Papp - Probity Medical ResearchJose Bajo-Arenas - Santa Cristina University HospitalDiane M HarperAureli Torné - Hospital Clínic-Institut d'Investigacions Biomèdiques August Pii Sunyer (IDIBAPSMarie-Pierre David - ,Frank Struyf - ,Matti Lehtinen - University of Tampere, TampereGary DubinHPV PATRICIA Study Group: Collaborators
- Contributors
- J T Stapleton (Contributor) - University of Iowa, Internal Medicine
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.208(9), pp.1391-1396
- DOI
- 10.1093/infdis/jit360
- PMID
- 24092907
- PMCID
- PMC3789574
- NLM abbreviation
- J Infect Dis
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Publisher
- Oxford University Press
- Language
- English
- Date published
- 11/01/2013
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094520702771
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