Efficient 169Yb high-dose-rate brachytherapy source production using reactivation

Ryan T Flynn; Quentin E Adams; Karolyn M Hopfensperger; Xiaodong Wu; Weiyu Xu; Yusung Kim

doi:10.1002/mp.13563

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Efficient 169Yb high-dose-rate brachytherapy source production using reactivation

Journal article

Open access

Peer reviewed

Efficient 169Yb high-dose-rate brachytherapy source production using reactivation

Ryan T Flynn, Quentin E Adams, Karolyn M Hopfensperger, Xiaodong Wu, Weiyu Xu and Yusung Kim

Medical physics (Lancaster), Vol.46(7), pp.2935-2943

07/2019

DOI: 10.1002/mp.13563

PMCID: PMC6905186

PMID: 31054163

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Abstract

To present and quantify the effectiveness of a method for the efficient production of Yb high-dose-rate brachytherapy sources with 27 Ci activity upon clinical delivery, which have about the same dose rate in water at 1 cm from the source center as 10 Ci Ir sources. A theoretical framework for Yb source activation and reactivation using thermal neutrons in a research reactor and Yb-Yb O precursor is derived and benchmarked against published data. The model is dependent primarily on precursor Yb enrichment percentage, active source volume of the active element, and average thermal neutron flux within the active source. Efficiency gains in Yb source production are achievable through reactivation, and the gains increase with active source volume. For an average thermal neutron flux within the active source of 1 × 10 n cm s , increasing the active source volume from 1 to 3 mm decreased reactor-days needed to generate one clinic-year of Yb from 256 days yr to 59 days yr , and 82%-enriched precursor dropped from 80 mg yr to 21 mg yr . A resource reduction of 74%-77% is predicted for an active source volume increase from 1 to 3 mm . Dramatic cost savings are achievable in Yb source production costs through reactivation if active sources larger than 1 mm are used.

Radiotherapy Dosage

Radiochemistry - methods

Radioisotopes - therapeutic use

Ytterbium - chemistry

Benchmarking

Brachytherapy

Radiation Dosage

Ytterbium - therapeutic use

Radioisotopes - chemistry

Details

Title: Subtitle: Efficient 169Yb high-dose-rate brachytherapy source production using reactivation
Creators: Ryan T Flynn - Department of Radiation Oncology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, 52242, USA
Quentin E Adams - Department of Radiation Oncology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, 52242, USA
Karolyn M Hopfensperger - Roy J. Carver Department of Biomedical Engineering, University of Iowa, 5601 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA, 52242, USA
Xiaodong Wu - Department of Electrical and Computer Engineering, University of Iowa, 4016 Seamans Center, for the Engineering Arts and Sciences, Iowa City, IA, 52242, USA
Weiyu Xu - Department of Electrical and Computer Engineering, University of Iowa, 4016 Seamans Center, for the Engineering Arts and Sciences, Iowa City, IA, 52242, USA
Yusung Kim - Department of Radiation Oncology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, 52242, USA
Resource Type: Journal article
Publication Details: Medical physics (Lancaster), Vol.46(7), pp.2935-2943
DOI: 10.1002/mp.13563
PMID: 31054163
PMCID: PMC6905186
NLM abbreviation: Med Phys
ISSN: 0094-2405
eISSN: 2473-4209
Publisher: United States
Grant note: R41 CA210737 / NCI NIH HHS 1 R41 CA210737-01 / National Cancer Institute Phase 1 Small Business Technology Transfer P30 CA086862 / NCI NIH HHS R01 EB020665 / NIBIB NIH HHS
Language: English
Date published: 07/2019
Academic Unit: Electrical and Computer Engineering; Radiation Oncology
Record Identifier: 9984047777602771

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