Journal article
Ehrlichiosis infection mimicking thrombotic microangiopathy syndrome early after kidney transplantation
Transplant infectious disease, Vol.22(5), pp.e13305-n/a
10/2020
DOI: 10.1111/tid.13305
PMID: 32358827
Abstract
Fever of unknown origin and the clinical picture of thrombotic microangiopathy (TMA) are diagnostic challenges in the early period after kidney transplantation. Here, we report a case of human monocytic ehrlichiosis in a renal allograft recipient who presented with fever and clinical picture of TMA in the first month post–kidney transplant. Despite broad coverage with multiple antimicrobial agents, fever and hematological abnormalities persisted for several days. A history of contact exposure and living in an endemic area raised clinical suspicion for human monocytic ehrlichiosis (HME), and empiric treatment with doxycycline was initiated. Definitive diagnosis of HME was confirmed by polymerase chain reaction (PCR) for Ehrlichia chaffeensis. Human ehrlichiosis should be considered within the differential diagnosis in kidney transplant recipients with the clinical picture of TMA and fever of unknown origin. Furthermore, early treatment with doxycycline enhances rapid resolution of clinical and laboratory recovery.
Details
- Title: Subtitle
- Ehrlichiosis infection mimicking thrombotic microangiopathy syndrome early after kidney transplantation
- Creators
- Waleed Hassan - University of Tennessee Health Science CenterManish Talwar - Methodist University HospitalVasanthi Balaraman - Methodist UniversityMiklos Z. Molnar - University of Tennessee Health Science Center
- Resource Type
- Journal article
- Publication Details
- Transplant infectious disease, Vol.22(5), pp.e13305-n/a
- DOI
- 10.1111/tid.13305
- PMID
- 32358827
- ISSN
- 1398-2273
- eISSN
- 1399-3062
- Number of pages
- 5
- Language
- English
- Date published
- 10/2020
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984738104902771
Metrics
3 Record Views