Journal article
Eight-point glucose testing versus the continuous glucose monitoring system in evaluation of glycemic control in type 1 diabetes
The journal of clinical endocrinology and metabolism, Vol.90(6), pp.3387-3391
06/2005
DOI: 10.1210/jc.2004-2510
PMID: 15784705
Abstract
Advantages/disadvantages of continuous vs. discrete glucose monitoring are not well documented.
Compare glucose profiles from home meters vs. continuous sensors.
Randomized clinical trial conducted by the Diabetes Research in Children Network (DirecNet) to assess the utility of the GlucoWatch G2 Biographer.
Home glucose measurements.
Two hundred children (age, 7 to < 18 yr) with type 1 diabetes.
At baseline, subjects were asked to wear the continuous glucose monitoring system (CGMS) sensor and perform meter tests at eight prespecified times of the day (eight-point testing) each for 3 d (2 d using both, 1 d eight-point testing only, 1 d CGMS only). Hemoglobin A1c was measured in a central laboratory.
Six-month hemoglobin A1c. This analysis looked at baseline glucose profiles/hemoglobin A1c.
Only 10% of subjects completed full eight-point testing for 3 d, but median CGMS use was 70 h. Mean glucose was lower when measured by the CGMS compared with eight-point testing (183 +/- 37 vs. 188 +/- 41 mg/dl; 10.2 +/- 2.1 vs.10.4 +/- 2.3 mmol/liter; P = 0.009), especially overnight (2400-0400 h; 174 vs. 199 mg/dl; 9.7 vs. 11.1 mmol/liter; P < 0.001). Associations of hemoglobin A1c with mean glucose were similar for eight-point testing [slope 23 mg/dl per 1% (1.3 mmol/liter); correlation 0.40; P < 0.001] and CGMS [slope 19 mg/dl per 1% (1.1 mmol/liter); correlation 0.39; P < 0.001]. Postprandial excursions were lower for eight-point testing vs. CGMS, especially after dinner (mean excursion -17 vs. 63 mg/dl; -1.0 vs. 3.5 mmol/liter; P < 0.001).
Both methods gave similar mean glucose profiles and associations with hemoglobin A1c. Advantages of the CGMS were higher density of data and better detection of postprandial peaks. However, the CGMS may overestimate the frequency of low glucose levels, especially overnight.
Details
- Title: Subtitle
- Eight-point glucose testing versus the continuous glucose monitoring system in evaluation of glycemic control in type 1 diabetes
- Creators
- Rosanna Fiallo-Scharer - Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, Florida 33647, USA. direcnet@jaeb.orgDiabetes Research in Children Network Study Group
- Contributors
- Michael J Tansey (Contributor) - University of Iowa, Stead Family Department of PediatricsEva Tsalikian (Contributor) - University of Iowa, Stead Family Department of Pediatrics
- Resource Type
- Journal article
- Publication Details
- The journal of clinical endocrinology and metabolism, Vol.90(6), pp.3387-3391
- DOI
- 10.1210/jc.2004-2510
- PMID
- 15784705
- ISSN
- 0021-972X
- eISSN
- 1945-7197
- Grant note
- HD041919-01 / NICHD NIH HHS U10 HD041915 / NICHD NIH HHS HD04191 / NICHD NIH HHS U10 HD041908 / NICHD NIH HHS U10 HD041906 / NICHD NIH HHS HD041908-01 / NICHD NIH HHS HD041918-0 / NICHD NIH HHS HD041906-01 / NICHD NIH HHS HD041890 / NICHD NIH HHS U01 HD041890 / NICHD NIH HHS U10 HD041918 / NICHD NIH HHS
- Language
- English
- Date published
- 06/2005
- Academic Unit
- Endocrinology and Diabetes; Stead Family Department of Pediatrics
- Record Identifier
- 9984093364402771
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