Journal article
Eight weeks of inorganic nitrate/nitrite supplementation improves aerobic exercise capacity and the gas exchange threshold in patients with type 2 diabetes
Journal of applied physiology, Vol.133(6), pp.1407-1414
11/03/2022
DOI: 10.1152/japplphysiol.00478.2022
PMCID: PMC9762960
PMID: 36326473
Abstract
Patients with type 2 diabetes mellitus (T2DM) have reduced exercise capacity, indexed by lower maximal oxygen consumption (V̇o2max) and achievement of the gas exchange threshold (GET) at a lower % V̇o2max. The ubiquitous signaling molecule nitric oxide (NO) plays a multifaceted role during exercise and, as patients with T2DM have poor endogenous NO production, we investigated if inorganic nitrate/nitrite supplementation (an exogenous source of NO) improves exercise capacity in patients with T2DM. Thirty-six patients with T2DM (10F, 59 ± 9 yr, 32.0 ± 5.1 kg/m2, HbA1c = 7.4 ± 1.4%) consumed beetroot juice containing either inorganic nitrate/nitrite (4.03 mmol/0.29 mmol) or a placebo (0.8 mmol/0.00 mmol) for 8 wk. A maximal exercise test was completed before and after both interventions. V̇o2max was determined by averaging 15-s data, whereas the GET was identified using the V-slope method and breath-by-breath data. Inorganic nitrate/nitrite increased both absolute (1.96 ± 0.67 to 2.07 ± 0.75 L/min) and relative (20.7 ± 7.0 to 21.9 ± 7.4 mL/kg/min, P < 0.05 for both) V̇o2max, whereas no changes were observed following placebo (1.94 ± 0.40 to 1.90 ± 0.39 L/min, P = 0.33; 20.0 ± 4.2 to 19.7 ± 4.6 mL/kg/min, P = 0.39). Maximal workload was also increased following inorganic nitrate/nitrite supplementation (134 ± 47 to 140 ± 51 W, P < 0.05) but not placebo (138 ± 32 to 138 ± 32 W, P = 0.98). V̇o2 at the GET (1.11 ± 0.27 to 1.27 ± 0.38L/min) and the %V̇o2max in which GET occurred (56 ± 8 to 61 ± 7%, P < 0.05 for both) increased following inorganic nitrate/nitrite supplementation but not placebo (1.10 ± 0.23 to 1.08 ± 0.21 L/min, P = 0.60; 57 ± 9 to 57 ± 8%, P = 0.90) although the workload at GET did not achieve statistical significance (group-by-time P = 0.06). Combined inorganic nitrate/nitrite consumption improves exercise capacity, maximal workload, and promotes a rightward shift in the GET in patients with T2DM. This manuscript reports data from a registered Clinical Trial at ClinicalTrials.gov ID: NCT02804932.
Details
- Title: Subtitle
- Eight weeks of inorganic nitrate/nitrite supplementation improves aerobic exercise capacity and the gas exchange threshold in patients with type 2 diabetes
- Creators
- Joshua M Bock - University of IowaBrady E Hanson - University of IowaKayla A Miller - University of IowaNathanael T Seaberg - University of IowaKenichi Ueda - University of IowaAndrew J Feider - University of IowaSatoshi Hanada - University of IowaVitor A Lira - University of IowaDarren P Casey - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology, Vol.133(6), pp.1407-1414
- DOI
- 10.1152/japplphysiol.00478.2022
- PMID
- 36326473
- PMCID
- PMC9762960
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Grant note
- DOI: 10.13039/100000041, name: American Diabetes Association, award: 1-16-1CTS-015; DOI: 10.13039/100000054, name: HHS | NIH | National Cancer Institute, award: P30CA086862
- Language
- English
- Date published
- 11/03/2022
- Academic Unit
- Anesthesia; Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center; Dental Research; Health and Human Physiology
- Record Identifier
- 9984309759902771
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