Electrical excitation of the acoustically sensitive auditory nerve: single-fiber responses to electric pulse trains

Charles A Miller; Paul J Abbas; Barbara K Robinson; Kirill V Nourski; Fawen Zhang; Fuh-Cherng Jeng

doi:10.1007/s10162-006-0036-9

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Electrical excitation of the acoustically sensitive auditory nerve: single-fiber responses to electric pulse trains

Journal article

Open access

Peer reviewed

Electrical excitation of the acoustically sensitive auditory nerve: single-fiber responses to electric pulse trains

Charles A Miller, Paul J Abbas, Barbara K Robinson, Kirill V Nourski, Fawen Zhang and Fuh-Cherng Jeng

Journal of the Association for Research in Otolaryngology, Vol.7(3), pp.195-210

09/2006

DOI: 10.1007/s10162-006-0036-9

PMCID: PMC2504607

PMID: 16708257

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Abstract

Nearly all studies on auditory-nerve responses to electric stimuli have been conducted using chemically deafened animals so as to more realistically model the implanted human ear that has typically been profoundly deaf. However, clinical criteria for implantation have recently been relaxed. Ears with "residual" acoustic sensitivity are now being implanted, calling for the systematic evaluation of auditory-nerve responses to electric stimuli as well as combined electric and acoustic stimuli in acoustically sensitive ears. This article presents a systematic investigation of single-fiber responses to electric stimuli in acoustically sensitive ears. Responses to 250 pulse/s electric pulse trains were collected from 18 cats. Properties such as threshold, dynamic range, and jitter were found to differ from those of deaf ears. Other types of fiber activity observed in acoustically sensitive ears (i.e., spontaneous activity and electrophonic responses) were found to alter the temporal coding of electric stimuli. The electrophonic response, which was shown to greatly change the information encoded by spike intervals, also exhibited fast adaptation relative to that observed in the "direct" response to electric stimuli. More complex responses, such as "buildup" (increased responsiveness to successive pulses) and "bursting" (alternating periods of responsiveness and unresponsiveness) were observed. Our findings suggest that bursting is a response unique to sustained electric stimulation in ears with functional hair cells.

Cochlear Nerve - physiology

Cats

Animals

Hair Cells, Auditory - physiology

Humans

Auditory Threshold - physiology

Deafness - physiopathology

Models, Animal

Signal Transduction - physiology

Cochlear Implants

Deafness - therapy

Deafness - chemically induced

Details

Title: Subtitle: Electrical excitation of the acoustically sensitive auditory nerve: single-fiber responses to electric pulse trains
Creators: Charles A Miller - Department of Otolaryngology, University of Iowa Hospitals & Clinics, 21201 PFP, 200 Hawkins Drive, Iowa City, IA 52242, USA. charles-miller@uiowa.edu
Paul J Abbas
Barbara K Robinson
Kirill V Nourski
Fawen Zhang
Fuh-Cherng Jeng
Resource Type: Journal article
Publication Details: Journal of the Association for Research in Otolaryngology, Vol.7(3), pp.195-210
DOI: 10.1007/s10162-006-0036-9
PMID: 16708257
PMCID: PMC2504607
NLM abbreviation: J Assoc Res Otolaryngol
ISSN: 1525-3961
eISSN: 1438-7573
Publisher: United States
Grant note: N01-DC-2-1005 / NIDCD NIH HHS
Language: English
Date published: 09/2006
Academic Unit: Communication Sciences and Disorders; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984040267402771

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