Journal article
Electrically evoked compound action potentials in adult and pediatric cochlear implant users: II. Assessing cochlear nerve health status with the interphase gap effect and the phase locking value
Hearing research, Vol.478, 109693
08/01/2026
DOI: 10.1016/j.heares.2026.109693
PMID: 42248046
Abstract
•Neural synchrony and CN fiber availability assessed in pediatric and adult CI users.•Adult, but not pediatric, CI users showed reduced CN neural synchrony at basal cochlear regions.•CN fiber availability did not vary systematically across cochlear regions in either group.•Neural synchrony differed between groups at basal, but not apical, electrode location.
This study characterized and compared neural synchrony in the cochlear nerve (CN) and the number of CN fibers activated by electrical stimulation. Neural synchrony was quantified using the phase locking value. The number of activated CN fibers was assessed using the effect of increasing the interphase gap (IPG) of biphasic pulses on the electrically evoked compound action potential (eCAP), referred to as the IPG effect. The study included 50 postlingually deafened adults and 51 pediatric cochlear implant (CI) users with Cochlear™ Nucleus® devices. PLV and IPG effect measures were obtained at four and three electrode locations in adults and pediatric participants, respectively. In adults, CN neural synchrony was significantly poorer at basal compared with more apical electrode locations. No such electrode-location effect was observed in pediatric participants. No electrode-location differences in the IPG effect were observed in either group. Compared with pediatric participants, adults showed significantly poorer CN neural synchrony at the most basal electrode location, but not at the most apical location. No group differences were observed in the IPG effect. No association was found between PLV and the IPG effect at any electrode location in either group. These findings are consistent with differences in CN health status between adult and pediatric CI users and further support the notion that PLV and the IPG effect reflect distinct underlying biological mechanisms rather than non-neural factors. Further studies are needed to clarify the relationship between age and these eCAP-derived measures in adult CI users.
Details
- Title: Subtitle
- Electrically evoked compound action potentials in adult and pediatric cochlear implant users: II. Assessing cochlear nerve health status with the interphase gap effect and the phase locking value
- Creators
- Shuman He - The Ohio State UniversityZi Gao - The Ohio State UniversityJacob J. Oleson - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Hearing research, Vol.478, 109693
- DOI
- 10.1016/j.heares.2026.109693
- PMID
- 42248046
- NLM abbreviation
- Hear Res
- ISSN
- 0378-5955
- eISSN
- 1878-5891
- Publisher
- Elsevier B.V
- Grant note
- National Institutes of Health: R01 DC017846, R21 DC019458, R01DC022051-01A1
This work was partially supported by grants from the National Institutes of Health awarded to SH [grant numbers: R01 DC017846, R21 DC019458 and R01DC022051-01A1] . The Funding organizations played no role in designing or conducting the study, collecting or analyzing the data, interpreting the results, preparing the manuscript, reviewing or approving its content, or deciding to submit it for publication.
- Language
- English
- Electronic publication date
- 06/01/2026
- Date published
- 08/01/2026
- Academic Unit
- Biostatistics; Otolaryngology
- Record Identifier
- 9985174501202771
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