Journal article
Electroconvulsive therapy induced gray matter increase is not necessarily correlated with clinical data in depressed patients
Brain stimulation, Vol.12(2), pp.335-343
03/2019
DOI: 10.1016/j.brs.2018.11.017
PMID: 30554869
Abstract
Electroconvulsive therapy (ECT) and depression have been associated with brain volume changes, especially in the hippocampus and the amygdala.
In this retrospective study we collected data from individual pre-post ECT whole brain magnetic resonance imaging scans of depressed patients from six German university hospitals. Gray matter volume (GMV) changes were quantified via voxel-based morphometry in a total sample of 92 patients with major depressive episodes (MDE). Additionally, 43 healthy controls were scanned twice within a similar time interval.
Most prominently longitudinal GMV increases occurred in temporal lobe regions. Within specific region of interests we detected significant increases of GMV in the hippocampus and the amygdala. These results were more pronounced in the right hemisphere. Decreases in GMV were not observed. GMV changes did not correlate with psychopathology, age, gender or number of ECT sessions. We ruled out white matter reductions as a possible indirect cause of the detected GMV increase.
The present findings support the notion of hippocampus and amygdala modulation following an acute ECT series in patients with MDE. These results corroborate the hypothesis that ECT enables primarily unspecific and regionally dependent neuroplasticity effects to the brain.
•ECT leads to a temporomesial gray matter volume increase in depressed patients.•This increase is focused on hippocampus and amygdala and slightly right-sided.•This increase does not correlate with basic clinical findings.•White matter loss is not a possible cause for the gray matter increase.
Details
- Title: Subtitle
- Electroconvulsive therapy induced gray matter increase is not necessarily correlated with clinical data in depressed patients
- Creators
- Alexander Sartorius - Research Group Translational Imaging, Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, GermanyTraute Demirakca - Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, GermanyAndreas Böhringer - Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, GermanyChristian Clemm von Hohenberg - Research Group Translational Imaging, Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, GermanySuna Su Aksay - Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, GermanyJan Malte Bumb - Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, GermanyLaura Kranaster - Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, GermanyThomas Nickl-Jockschat - Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, GermanyMichael Grözinger - Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, GermanyPhilipp A Thomann - Department of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, GermanyRobert Christian Wolf - Department of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, GermanyPeter Zwanzger - kbo-Inn-Salzach-Hospital, Gabersee 7, 83512, Wasserburg am Inn, GermanyUdo Dannlowski - Department of Psychiatry and Psychotherapy, Albert-Schweitzer-Campus 1, University of Muenster, GermanyRonny Redlich - Department of Psychiatry and Psychotherapy, Albert-Schweitzer-Campus 1, University of Muenster, GermanyMaxim Zavorotnyy - Department of Psychiatry and Psychotherapy, University of Marburg, GermanyRebecca Zöllner - Department of Psychiatry and Psychotherapy, University of Marburg, GermanyIsabel Methfessel - Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, GermanyMatthias Besse - Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, GermanyDavid Zilles - Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, GermanyGabriele Ende - Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany
- Resource Type
- Journal article
- Publication Details
- Brain stimulation, Vol.12(2), pp.335-343
- DOI
- 10.1016/j.brs.2018.11.017
- PMID
- 30554869
- NLM abbreviation
- Brain Stimul
- ISSN
- 1935-861X
- eISSN
- 1876-4754
- Publisher
- Elsevier Inc
- Grant note
- name: Systems Neuroscience and Imaging in Psychiatry (SNIP) Lab; name: University Medical Center, Göttingen; name: Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg; name: Innovative Medizinische Forschung, award: RE111604, RE111722; name: German Research Foundation (DFG, award: FOR2107 DA1151/5-1, DA1151/5-2; name: Interdisciplinary Center for Clinical Research, award: Dan3/012/17; name: University Medical Center Giessen and Marburg, award: 27/2015, FI22; name: Behring-Roentgen Foundation, award: 64-0016; name: German Research Foundation (DFG, award: 4689/3-1, 1869/14-1
- Language
- English
- Date published
- 03/2019
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984003948302771
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