Electrophysiological correlates of reward prediction error recorded in the human prefrontal cortex

Hiroyuki Oya; Ralph Adolphs; Hiroto Kawasaki; Antoine Bechara; Antonio Damasio; Matthew A Howard III

doi:10.1073/pnas.0500899102

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Electrophysiological correlates of reward prediction error recorded in the human prefrontal cortex

Journal article

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Peer reviewed

Electrophysiological correlates of reward prediction error recorded in the human prefrontal cortex

Hiroyuki Oya, Ralph Adolphs, Hiroto Kawasaki, Antoine Bechara, Antonio Damasio and Matthew A Howard III

Proceedings of the National Academy of Sciences - PNAS, Vol.102(23), pp.8351-8356

06/07/2005

DOI: 10.1073/pnas.0500899102

PMCID: PMC1149421

PMID: 15928095

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Abstract

Lesion and functional imaging studies have shown that the ventromedial prefrontal cortex is critically involved in the avoidance of risky choices. However, detailed descriptions of the mechanisms that underlie the establishment of such behaviors remain elusive, due in part to the spatial and temporal limitations of available research techniques. We investigated this issue by recording directly from prefrontal depth electrodes in a rare neurosurgical patient while he performed the Iowa Gambling Task, and we concurrently measured behavioral, autonomic, and electrophysiological responses. We found a robust alpha-band component of event-related potentials that reflected the mismatch between expected outcomes and actual outcomes in the task, correlating closely with the reward-related error obtained from a reinforcement learning model of the patient's choice behavior. The finding implicates this brain region in the acquisition of choice bias by means of a continuous updating of expectations about reward and punishment.

Biological Sciences

decision-making

emotion

Details

Title: Subtitle: Electrophysiological correlates of reward prediction error recorded in the human prefrontal cortex
Creators: Hiroyuki Oya - Departments of
Ralph Adolphs - Departments of
Hiroto Kawasaki - Departments of
Antoine Bechara - Departments of
Antonio Damasio - Departments of
Matthew A Howard III - University of Iowa, Neurosurgery
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.102(23), pp.8351-8356
DOI: 10.1073/pnas.0500899102
PMID: 15928095
PMCID: PMC1149421
NLM abbreviation: Proc Natl Acad Sci U S A
ISSN: 0027-8424
eISSN: 1091-6490
Publisher: National Academy of Sciences
Language: English
Date published: 06/07/2005
Academic Unit: Neurology; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984020653702771

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