Journal article
Electrospun Polycaprolactone 3D Nanofibrous Scaffold with Interconnected and Hierarchically Structured Pores for Bone Tissue Engineering
Advanced healthcare materials, Vol.4(15), pp.2238-2246
10/2015
DOI: 10.1002/adhm.201500345
PMID: 26332611
Abstract
For the first time, electrospun polycaprolactone (PCL) 3D nanofibrous scaffold has been developed by an innovative and convenient approach (i.e., thermally induced nanofiber self-agglomeration followed by freeze drying), and the scaffold possesses interconnected and hierarchically structured pores including macropores with sizes up to ≈300 μm. The novel PCL 3D scaffold is soft and elastic with very high porosity of ≈96.4%, thus it is morphologically/structurally similar to natural extracellular matrix and well suited for cell functions and tissue formation. The in vitro studies reveal that the scaffold can lead to high cell viability; more importantly, it is able to promote more potent BMP2-induced chondrogenic than osteogenic differentiation of mouse bone marrow mesenchymal stem cells. Consistent to the in vitro findings, the in vivo results indicate that the electrospun PCL 3D scaffold acts as a favorable synthetic extracellular matrix for functional bone regeneration through the physiological endochondral ossification process. © 2015 WILEY-VCH Verlag GmbH
Details
- Title: Subtitle
- Electrospun Polycaprolactone 3D Nanofibrous Scaffold with Interconnected and Hierarchically Structured Pores for Bone Tissue Engineering
- Creators
- Tao Xu - South Dakota School of Mines and TechnologyJacob M. Miszuk - University of South DakotaYong Zhao - South Dakota School of Mines and TechnologyHongli Sun - University of South DakotaHao Fong - South Dakota School of Mines and Technology
- Resource Type
- Journal article
- Publication Details
- Advanced healthcare materials, Vol.4(15), pp.2238-2246
- DOI
- 10.1002/adhm.201500345
- PMID
- 26332611
- NLM abbreviation
- Adv Healthc Mater
- ISSN
- 2192-2640
- eISSN
- 2192-2659
- Publisher
- Blackwell Publishing Ltd
- Number of pages
- 9
- Grant note
- name: National Science Foundation, award: EPS-1355423
- Language
- English
- Date published
- 10/2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Craniofacial Anomalies Research Center; Oral and Maxillofacial Surgery; Dental Research
- Record Identifier
- 9984367720602771
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