Journal article
Elevated AF1q expression is a poor prognostic marker for adult acute myeloid leukemia patients with normal cytogenetics
American journal of hematology, Vol.84(5), pp.308-309
05/2009
DOI: 10.1002/ajh.21396
PMID: 19396856
Abstract
Nearly half of the patients with newly diagnosed acute myeloid leukemia have normal cytogenetics (NC-AML) and are classified as intermediate risk, but their 5-year overall survival (OS) ranges from 24 to 42%. Therefore, molecular biomarkers to identify poor-risk patients are needed. Elevated AF1q expression in the absence of specific poor cytogenetics is associated with poor outcomes in pediatric patients with AML and adult patients with myelodysplastic syndrome. We examined AF1q expression in 290 patients with NC-AML. We found that patients with low AF1q (n = 73) expression (AF1q(low)) have better OS (P = 0.026), disease-free survival (P = 0.1), and complete remission rate (P = 0.06) when compared with patients with high AF1q expression (AF1q(high) n = 217). The patients with AF1q(high) had significantly greater incidence of concurrent tyrosine kinase3 internal tandem duplication. A subgroup of the patients with AF1q(high) who received allogeneic stem cell transplantation (SCT) had a significant better relapse-free survival when compared with patients who received chemotherapy/autologous SCT (P = 0.04). This study suggests that high AF1q expression is a poor prognostic marker for adult patients with NC-AML.
Details
- Title: Subtitle
- Elevated AF1q expression is a poor prognostic marker for adult acute myeloid leukemia patients with normal cytogenetics
- Creators
- Crawford J Strunk - Case Western Reserve UniversityUwe Platzbecker - Medical Clinic and Polyclinic I, University Hospital Dresden “Carl Gustav Carus,” Dresden, GermanyChristian Thiede - Medical Clinic and Polyclinic I, University Hospital Dresden “Carl Gustav Carus,” Dresden, GermanyMarkus Schaich - Medical Clinic and Polyclinic I, University Hospital Dresden “Carl Gustav Carus,” Dresden, GermanyThomas Illmer - Medical Clinic and Polyclinic I, University Hospital Dresden “Carl Gustav Carus,” Dresden, GermanyZizhen Kang - Case Western Reserve UniversityPatrick Leahy - Case Western Reserve UniversityChunbiao Li - Case Western Reserve UniversityXiuyan Xie - Case Western Reserve UniversityMary J Laughlin - Case Western Reserve UniversityHillard M Lazarus - Case Western Reserve UniversityStanton L Gerson - Case Western Reserve UniversityKevin D Bunting - Case Western Reserve UniversityGerhard Ehninger - Medical Clinic and Polyclinic I, University Hospital Dresden “Carl Gustav Carus,” Dresden, GermanyWilliam Tse - Case Western Reserve University
- Resource Type
- Journal article
- Publication Details
- American journal of hematology, Vol.84(5), pp.308-309
- DOI
- 10.1002/ajh.21396
- PMID
- 19396856
- NLM abbreviation
- Am J Hematol
- ISSN
- 0361-8609
- eISSN
- 1096-8652
- Grant note
- NIH/T32 / PHS HHS NIH/K12 / PHS HHS
- Language
- English
- Date published
- 05/2009
- Academic Unit
- Pathology; Iowa Neuroscience Institute
- Record Identifier
- 9984201115702771
Metrics
17 Record Views