Journal article
Elevated C-Reactive Protein Is Related to Cognitive Decline in Older Adults with Cardiovascular Disease
Journal of the American Geriatrics Society (JAGS), Vol.56(10), pp.1898-1903
2008
DOI: 10.1111/j.1532-5415.2008.01930.x
PMCID: PMC2704859
PMID: 18771451
Abstract
Objectives: To prospectively relate C-reactive protein (CRP), a systemic marker of inflammation, to cognitive change over a 1-year follow-up period.
Design: Prospective 1-year follow-up.
Setting: Outpatient university medical setting.
Participants: Seventy-eight adults (aged 56-84; 39% female) with cardiovascular disease.
Measurements: CRP levels were measured using a high-sensitivity assay, and participants completed a neuropsychological battery at study entry. Neuropsychological assessment was repeated 1 year later.
Results: The association between CRP and change in cognition over the 1-year follow-up was examined using hierarchical linear regression modeling for five cognitive domains (global cognition, language, memory, visuospatial abilities, and attention-executive-psychomotor). High CRP levels were associated with subtle declines in attention-executive-psychomotor performance (CRP beta=-0.22, P=.04) after adjusting for the effects of age and cognitive performance at study entry. CRP was not significantly associated with change in language, memory, or visuospatial performance.
Conclusion: These data provide preliminary evidence that inflammation, potentially contributing to atherosclerotic processes, may underlie the association between high CRP and changes in attention-executive-psychomotor performance.
Details
- Title: Subtitle
- Elevated C-Reactive Protein Is Related to Cognitive Decline in Older Adults with Cardiovascular Disease
- Creators
- Karin F HOTH - Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, United StatesAndreana P HALEY - Department of Psychology, University of Texas at Austin, Austin, Texas, United StatesJohn GUNSTAD - Department of Psychology, Kent State University, Kent, Ohio, United StatesRobert H PAUL - Department of Psychology and Behavioral Neuroscience, University of Missouri at St. Louis, St. Louis, Missouri, United StatesAthena POPPAS - Departments of Cardiology and Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, Rhode Island, United StatesAngela L JEFFERSON - Department of Neurology, Alzheimer's Disease Center, School of Medicine, Boston University, Boston, Massachusetts, United StatesDavid F TATE - Center for Neurological Imaging, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United StatesMakoto ONO - Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, United StatesBeth A JERSKEY - Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, United StatesRonald A COHEN - Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, United States
- Resource Type
- Journal article
- Publication Details
- Journal of the American Geriatrics Society (JAGS), Vol.56(10), pp.1898-1903
- DOI
- 10.1111/j.1532-5415.2008.01930.x
- PMID
- 18771451
- PMCID
- PMC2704859
- NLM abbreviation
- J Am Geriatr Soc
- ISSN
- 0002-8614
- eISSN
- 1532-5415
- Publisher
- Wiley-Blackwell; Hoboken, NJ
- Language
- English
- Date published
- 2008
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984066147502771
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