Journal article
Elevated Muscle Sympathetic Nerve Activity Contributes to Central Artery Stiffness in Young and Middle-Age/Older Adults
Hypertension (Dallas, Tex. 1979), Vol.73(5), pp.1025-1035
05/2019
DOI: 10.1161/HYPERTENSIONAHA.118.12462
PMCID: PMC6937199
PMID: 30905199
Abstract
Muscle sympathetic nerve activity (MSNA) influences the mechanical properties (ie, vascular smooth muscle tone and stiffness) of peripheral arteries, but it remains controversial whether MSNA contributes to stiffness of central arteries, such as the aorta and carotids. We examined whether elevated MSNA (age-related) would be independently associated with greater stiffness of central (carotid-femoral pulse wave velocity [PWV]) and peripheral (carotid-brachial PWV) arteries, in addition to lower carotid compliance coefficient, in healthy men and women (n=88, age: 19-73 years, 52% men). We also examined whether acute elevations in MSNA without increases in mean arterial pressure using graded levels of lower body negative pressure would augment central and peripheral artery stiffness in young (n=15, 60% men) and middle-age/older (MA/O, n=14, 43% men) adults. Resting MSNA burst frequency (bursts·min
) was significantly correlated with carotid-femoral PWV ( R=0.44, P<0.001), carotid-brachial PWV ( R=0.32, P=0.004), and carotid compliance coefficient ( R=0.28, P=0.01) after controlling for sex, mean arterial pressure, heart rate, and waist-to-hip ratio (central obesity), but these correlations were abolished after further controlling for age (all P>0.05). In young and MA/O adults, MSNA was elevated during lower body negative pressure ( P<0.001) and produced significant increases in carotid-femoral PWV (young: Δ+1.3±0.3 versus MA/O: Δ+1.0±0.3 m·s
, P=0.53) and carotid-brachial PWV (young: Δ+0.7±0.3 versus MA/O: Δ+0.7±0.5 m·s
, P=0.92), whereas carotid compliance coefficient during lower body negative pressure was significantly reduced in young but not MA/O (young: Δ-0.04±0.01 versus MA/O: Δ0.001±0.008 mm
·mm Hg
, P<0.01). Collectively, these data demonstrate the influence of MSNA on central artery stiffness and its potential contribution to age-related increases in stiffness of both peripheral and central arteries.
Details
- Title: Subtitle
- Elevated Muscle Sympathetic Nerve Activity Contributes to Central Artery Stiffness in Young and Middle-Age/Older Adults
- Creators
- Seth W Holwerda - Abboud Cardiovascular Research Center (S.W.H., F.M.A., G.L.P.)Rachel E Luehrs - From the Department of Health and Human Physiology (S.W.H., R.E.L., M.T.C., N.A.W., G.L.P.)Lyndsey DuBose - University of Iowa (L.D.)Michael T Collins - From the Department of Health and Human Physiology (S.W.H., R.E.L., M.T.C., N.A.W., G.L.P.)Nealy A Wooldridge - From the Department of Health and Human Physiology (S.W.H., R.E.L., M.T.C., N.A.W., G.L.P.)Amy K Stroud - Department of Psychiatry (A.K.S.)Paul J Fadel - Department of Kinesiology, University of Texas at Arlington (P.J.F.)Francois M Abboud - Department of Molecular Physiology and Biophysics (F.M.A.)Gary L Pierce - Fraternal Order of Eagles Diabetes Research Center (G.L.P.)
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.73(5), pp.1025-1035
- Publisher
- United States
- DOI
- 10.1161/HYPERTENSIONAHA.118.12462
- PMID
- 30905199
- PMCID
- PMC6937199
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Grant note
- P01 HL014388 / NHLBI NIH HHS UL1 TR002537 / NCATS NIH HHS T32 HL007121 / NHLBI NIH HHS T35 HL007485 / NHLBI NIH HHS
- Language
- English
- Date published
- 05/2019
- Academic Unit
- Molecular Physiology and Biophysics; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984002319802771
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