Elevated Phenotypic Switching and Drug Resistance of Candida albicans from Human Immunodeficiency Virus-Positive Individuals prior to First Thrush Episode

Kaaren Vargas; Shawn A Messer; Michael Pfaller; Shawn R Lockhart; Jack T Stapleton; John Hellstein; David R Soll

doi:10.1128/JCM.38.10.3595-3607.2000

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Elevated Phenotypic Switching and Drug Resistance of Candida albicans from Human Immunodeficiency Virus-Positive Individuals prior to First Thrush Episode

Journal article

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Peer reviewed

Elevated Phenotypic Switching and Drug Resistance of Candida albicans from Human Immunodeficiency Virus-Positive Individuals prior to First Thrush Episode

Kaaren Vargas, Shawn A Messer, Michael Pfaller, Shawn R Lockhart, Jack T Stapleton, John Hellstein and David R Soll

Journal of clinical microbiology, Vol.38(10), pp.3595-3607

10/2000

DOI: 10.1128/JCM.38.10.3595-3607.2000

PMCID: PMC87443

PMID: 11015370

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Abstract

Strains of Candida albicans obtained from human immunodeficiency virus (HIV)-positive individuals prior to their first episode of oral thrush were already in a high-frequency mode of switching and were far more resistant to a number of antifungal drugs than commensal isolates from healthy individuals. Switching in these isolates also had profound effects both on susceptibility to antifungal drugs and on the levels of secreted proteinase activity. These results suggest that commensal strains colonizing HIV-positive individuals either undergo phenotypic alterations or are replaced prior to the first episode of oral thrush. They also support the suggestion that high-frequency phenotypic switching functions as a higher-order virulence trait, spontaneously generating in colonizing populations variants with alterations in a variety of specific virulence traits.

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Details

Title: Subtitle: Elevated Phenotypic Switching and Drug Resistance of Candida albicans from Human Immunodeficiency Virus-Positive Individuals prior to First Thrush Episode
Creators: Kaaren Vargas - College of Dentistry
Shawn A Messer - College of Dentistry
Michael Pfaller - College of Dentistry
Shawn R Lockhart - College of Dentistry
Jack T Stapleton - College of Dentistry
John Hellstein - College of Dentistry
David R Soll - College of Dentistry
Resource Type: Journal article
Publication Details: Journal of clinical microbiology, Vol.38(10), pp.3595-3607
Publisher: American Society for Microbiology
DOI: 10.1128/JCM.38.10.3595-3607.2000
PMID: 11015370
PMCID: PMC87443
ISSN: 0095-1137
eISSN: 1098-660X
Language: English
Date published: 10/2000
Academic Unit: Oral Pathology, Radiology and Medicine; Microbiology and Immunology; Infectious Diseases; Epidemiology; Pathology; Biology; Internal Medicine
Record Identifier: 9984094876402771

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