Journal article
Elevated delta OD 450 due to transient abnormal myelopoiesis in a Down syndrome fetus with hepatosplenomegaly on ultrasound
Prenatal diagnosis, Vol.34(3), pp.299-301
03/01/2014
DOI: 10.1002/pd.4299
PMID: 24353262
Abstract
Transient abnormal myelopoiesis (TAM) is a relatively common finding in children with Down syndrome but has also been diagnosed prenatally, most often presenting with fetal hepatosplenomegaly. We report a case of TAM with hepatosplenomegaly found on ultrasound and associated with an increased amniotic fluid Delta OD 450 value. TAM is most commonly transient but can be associated with fatality and therefore should be considered in the differential diagnosis when fetal hepatosplenomegaly is found on ultrasound. Amniocentesis with chromosomal analysis and a Delta OD 450 may aid in diagnosing TAM and predicting the severity of the liver involvement. (c) 2013 John Wiley & Sons, Ltd.
Details
- Title: Subtitle
- Elevated delta OD 450 due to transient abnormal myelopoiesis in a Down syndrome fetus with hepatosplenomegaly on ultrasound
- Creators
- Abigail Mancuso - University of Iowa Hospitals and ClinicsAsha Rijhsinghani - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Prenatal diagnosis, Vol.34(3), pp.299-301
- Publisher
- Wiley
- DOI
- 10.1002/pd.4299
- PMID
- 24353262
- ISSN
- 0197-3851
- eISSN
- 1097-0223
- Number of pages
- 3
- Language
- English
- Date published
- 03/01/2014
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984318223002771
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