Journal article
Elevated levels of 1-hydroxypyrene and N '-nitrosonornicotine in smokers with head and neck cancer: A matched control study
Head & neck, Vol.35(8), pp.1096-1100
08/2013
DOI: 10.1002/hed.23085
PMCID: PMC4418651
PMID: 22807150
Abstract
BackgroundHead and neck squamous cell carcinoma (HNSCC) is associated with tobacco use. Still, most smokers do not develop HNSCC. The mechanisms of varying susceptibility to HNSCC are poorly studied to date. Tobacco metabolite research provides insight regarding the innate metabolism and excretion of carcinogens.
MethodsSmokers with HNSCC (cases) were compared with smokers without HNSCC (controls) in a matched cohort. The tobacco metabolites studied were: 1-hydroxypyrene (1-HOP), N-nitrosonornicotine (NNN), and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL).
ResultsIn 33 subjects, mean 1-HOP was 1.82 pmol/mg creatinine versus 1.08 pmol/mg creatinine (p = .004) and mean NNN was 0.10 pmol/mg creatinine versus 0.04 pmol/mg creatinine (p = .01) in cases and controls, respectively. NNAL did not differ between groups.
ConclusionsSmokers with HNSCC have elevated urinary levels of 1-HOP and total NNN compared with matched controls, suggesting an increased effective exposure to these carcinogens. Tobacco constituent metabolites may be useful in understanding tobacco-related carcinogenesis in HNSCC. (c) 2012 Wiley Periodicals, Inc. Head Neck, 2013
Details
- Title: Subtitle
- Elevated levels of 1-hydroxypyrene and N '-nitrosonornicotine in smokers with head and neck cancer: A matched control study
- Creators
- Samir S. Khariwala - University of Minnesota Medical CenterSteven G. Carmella - University of Minnesota Medical CenterIrina Stepanov - University of Minnesota Medical CenterPatricia Fernandes - University of MinnesotaAmy Anne Lassig - University of MinnesotaBevan Yueh - University of Minnesota Medical CenterDorothy Hatsukami - University of Minnesota Medical CenterStephen S. Hecht - University of Minnesota Medical Center
- Resource Type
- Journal article
- Publication Details
- Head & neck, Vol.35(8), pp.1096-1100
- DOI
- 10.1002/hed.23085
- PMID
- 22807150
- PMCID
- PMC4418651
- NLM abbreviation
- Head Neck
- ISSN
- 1043-3074
- eISSN
- 1097-0347
- Publisher
- Wiley
- Number of pages
- 5
- Grant note
- Minnesota Medical Foundation
- Language
- English
- Date published
- 08/2013
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984966748002771
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