Journal article
Elevated lipoprotein(a) levels linked to new-onset atrial fibrillation: insights from a retrospective cohort study
European journal of preventive cardiology, Vol.32(9), pp.769-777
07/2025
DOI: 10.1093/eurjpc/zwaf063
PMID: 39919039
Abstract
Aims Atrial fibrillation (AF) is the most common cardiac arrhythmia. Although lipoprotein(a) [Lp(a)] is known to be a well-established risk factor for atherosclerotic cardiovascular disease, its role in the development of AF, independent of this association, remains unclear. Methods and results Adult patients from the three Mayo Clinic sites with a baseline Lp(a) and without AF history were included. Patients were categorized into two groups based on their Lp(a) levels: high Lp(a) (>= 50 mg/dL) and low Lp(a) (<50 mg/dL). Survival probabilities free from incident AF were compared between Lp(a) groups, during a follow-up period up to 15 years, using the Kaplan-Meier curve and the log-rank test. Multivariable Cox regression analysis was also conducted. A total of 75 376 patients were included (median age: 55 years, 59% males), with a median follow-up duration of 8.8 (inter-quartile range: 3.4, 14.8) years. Incident AF was detected in 5738 (7.6%) patients. Survival probability free from incident AF was significantly lower in patients with elevated Lp(a) (86%) compared with those with low Lp(a) (88%, log-rank P < 0.001). Multivariable analysis adjusted for potential risk factors of AF showed a statistically significant association of elevated Lp(a) with an 11% increase in AF risk (adjusted hazard ratio: 1.11, 95% confidence interval: 1.05-1.18). Conclusion Our study suggests that elevated Lp(a) (>= 50 mg/dL) is an independent risk factor for incident AF. Future prospective studies are warranted to validate our results and to test if reducing Lp(a) could mitigate the burden of AF.
Details
- Title: Subtitle
- Elevated lipoprotein(a) levels linked to new-onset atrial fibrillation: insights from a retrospective cohort study
- Creators
- Kamal Awad - Mayo Clinic in FloridaMoaz Kamel - Mayo Clinic in FloridaAhmed K. Mahmoud - Mayo Clinic in FloridaJuan M. Farina - Mayo Clinic in FloridaAmro Badr - Mayo Clinic in FloridaMilagros Pereyra Pietri - PhoenixIsabel G. Scalia - Mayo Clinic in FloridaMohammed Tiseer Abbas - Mayo Clinic in FloridaNima Baba Ali - Mayo Clinic in FloridaSaid Alsidawi - Mayo Clinic in FloridaSteven J. Lester - Mayo Clinic in FloridaAnan Abu Rmilah - Mayo ClinicTimothy Barry - Mayo Clinic in FloridaWin-Kuang Shen - Mayo Clinic in FloridaKomandoor Srivathsan - Mayo Clinic in FloridaLuis R. Scott - Mayo Clinic in FloridaHicham El Masry - Mayo Clinic in FloridaArturo M. Valverde - Mayo Clinic in FloridaMayank Sardana - Mayo Clinic in FloridaDan Sorajja - Mayo Clinic in FloridaChadi Ayoub - Mayo Clinic in FloridaReza Arsanjani - Mayo Clinic in Florida
- Resource Type
- Journal article
- Publication Details
- European journal of preventive cardiology, Vol.32(9), pp.769-777
- DOI
- 10.1093/eurjpc/zwaf063
- PMID
- 39919039
- NLM abbreviation
- Eur J Prev Cardiol
- ISSN
- 2047-4873
- eISSN
- 2047-4881
- Publisher
- Oxford Univ Press
- Number of pages
- 9
- Language
- English
- Electronic publication date
- 02/07/2025
- Date published
- 07/2025
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984845669802771
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