Journal article
Elevated plasma levels of interleukin-6 in postmenopausal women do not correlate with bone density
Journal of the American Geriatrics Society (JAGS), Vol.43(3), pp.236-239
1995
DOI: 10.1111/j.1532-5415.1995.tb07328.x
PMID: 7884109
Abstract
Objective: To determine if plasma levels of Interleukin-6 (IL-6) across the lifespan correlate with bone density or plasma osteocalcin.
Design: Cross-sectional study.
Participants: Forty-five healthy community-dwelling volunteers aged 25-74 years. Exclusion criteria were smoking use of medications known to affect bone metabolism (corticosteroids, heparin, thyroxine, thiazides, and anticonvulsants), and presence of chronic inflammatory disease.
Measurements: Bone density was measured by dual-energy X-ray absorptiometry at the femoral neck and lumbar spine. Plasma levels of IL-6 and osteocalcin were determined by ELISA and RIA, respectively.
Results: Plasma levels of IL-6 increased with advancing age (P < .0001) and correlated with postmenopausal status (P < .0001). No correlation was observed between plasma IL-6 level and bone mineral density at either the lumbar spine or femoral neck, and none was observed with plasma osteocalcin.
Conclusions: The elevation of plasma IL-6 observed following menopause is consistent with the proposed importance of estrogen in the regulation of IL-6. These findings do not provide support for a role of IL-6 in determination of peak bone density or subsequent development of osteoporosis. However, it is possible that plasma levels of IL-6 differ from those in the bone microenvironment.
Details
- Title: Subtitle
- Elevated plasma levels of interleukin-6 in postmenopausal women do not correlate with bone density
- Creators
- D. M KANIA - Univ. Wisconsin-Madison, dep. medicine, Madison WI, United StatesN BINKLEY - Univ. Wisconsin-Madison, dep. medicine, Madison WI, United StatesM CHECOVICH - Univ. Wisconsin-Madison, dep. medicine, Madison WI, United StatesT HAVIGHURST - Univ. Wisconsin-Madison, dep. medicine, Madison WI, United StatesM SCHILLING - Univ. Wisconsin-Madison, dep. medicine, Madison WI, United StatesW. B ERSHLER - Univ. Wisconsin-Madison, dep. medicine, Madison WI, United States
- Resource Type
- Journal article
- Publication Details
- Journal of the American Geriatrics Society (JAGS), Vol.43(3), pp.236-239
- Publisher
- Blackwell; Malden, MA
- DOI
- 10.1111/j.1532-5415.1995.tb07328.x
- PMID
- 7884109
- ISSN
- 0002-8614
- eISSN
- 1532-5415
- Language
- English
- Date published
- 1995
- Academic Unit
- Family and Community Medicine; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984024560002771
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