Elevated prevalence of obesity, metabolic syndrome, and cardiovascular risk factors in bipolar disorder

Jess G Fiedorowicz; Narasimha M Palagummi; Valerie L Forman-Hoffman; Del D Miller; William G Haynes

doi:10.1080/10401230802177722

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Elevated prevalence of obesity, metabolic syndrome, and cardiovascular risk factors in bipolar disorder

Journal article

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Peer reviewed

Elevated prevalence of obesity, metabolic syndrome, and cardiovascular risk factors in bipolar disorder

Jess G Fiedorowicz, Narasimha M Palagummi, Valerie L Forman-Hoffman, Del D Miller and William G Haynes

Annals of clinical psychiatry, Vol.20(3), pp.131-137

2008

DOI: 10.1080/10401230802177722

PMCID: PMC2776768

PMID: 18633739

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Abstract

Background. Bipolar disorder is associated with excess cardiovascular mortality. We hypothesized outpatients with bipolar disorder would exhibit excess cardiovascular risk factors, particularly among prevalent users of the second-generation antipsychotics associated with weight gain and valproic acid derivatives. Methods. This chart review of 217 patients with bipolar disorder examined cardiovascular risk factors of the metabolic syndrome. We also evaluated if certain medications were cross-sectionally associated with metabolic syndrome. Results. Fifty-six patients were not weighed and many did not have available lipid profiles. Over three-quarters of those with available data (n = 161) were overweight or obese (body mass index ≥ 25) and nearly half were obese (body mass index ≥ 30). A prevalence exceeding general population estimates was also observed for hypertriglyceridemia, elevated blood pressure/hypertension, and elevated fasting glucose/diabetes. Among those with all requisite data (n = 60), over 50% met criteria for National Cholesterol Education Program-defined metabolic syndrome, nearly double the expected prevalence. A trend toward greater prevalence of metabolic syndrome among prevalent users of the second-generation antipsychotics associated with weight gain was observed. Conclusions. Obesity and the metabolic syndrome were common in patients with bipolar disorder. These patients may be under-evaluated for cardiovascular risk and warrant screening and early intervention.

Metabolic Syndrome

Hypertension

Obesity

bipolar disorder

hyperlipidemia

diabetes mellitus

Details

Title: Subtitle: Elevated prevalence of obesity, metabolic syndrome, and cardiovascular risk factors in bipolar disorder
Creators: Jess G Fiedorowicz - College of Public Health, The University of Iowa, Iowa City, Iowa
Narasimha M Palagummi - College of Public Health, The University of Iowa, Iowa City, Iowa
Valerie L Forman-Hoffman - College of Public Health, The University of Iowa, Iowa City, Iowa
Del D Miller - College of Public Health, The University of Iowa, Iowa City, Iowa
William G Haynes - College of Public Health, The University of Iowa, Iowa City, Iowa
Resource Type: Journal article
Publication Details: Annals of clinical psychiatry, Vol.20(3), pp.131-137
DOI: 10.1080/10401230802177722
PMID: 18633739
PMCID: PMC2776768
NLM abbreviation: Ann Clin Psychiatry
ISSN: 1040-1237
eISSN: 1547-3325
Language: English
Date published: 2008
Academic Unit: Psychiatry; Epidemiology; Internal Medicine
Record Identifier: 9984004192302771

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