Elevation of retinyl ester level in the lungs of rats following repeated intraperitoneal injections of retinoic acid or retinoyl glucuronide

Arun B Barua; Stephen E McGowan; Kristi D Ivanoff; Bhabesh C Goswami; James A Olson

doi:10.1016/j.pupt.2003.12.001

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Elevation of retinyl ester level in the lungs of rats following repeated intraperitoneal injections of retinoic acid or retinoyl glucuronide

Journal article

Peer reviewed

Elevation of retinyl ester level in the lungs of rats following repeated intraperitoneal injections of retinoic acid or retinoyl glucuronide

Arun B Barua, Stephen E McGowan, Kristi D Ivanoff, Bhabesh C Goswami and James A Olson

Pulmonary pharmacology & therapeutics, Vol.17(3), pp.113-119

2004

DOI: 10.1016/j.pupt.2003.12.001

PMID: 15123219

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Abstract

Retinoic acid (RA) is involved in the development of both the conducting airway and alveolar portions of the lung. RA plays a key role in the induction of the formation of alveolar septa. Retinoyl beta-glucuronide (RAG), an endogenous retinoid, acts like RA, but is much less cytotoxic. We examined the effect of daily intraperitoneal doses of RA and RAG (1.66 micromol/kg) in dimethyl sulfoxide (DMSO) and cotton seed oil on the stores of retinol and retinyl ester (RE) in the lung of rats. In two separate experiments, one involving normal rats, and the other involving elastase-treated rats, there was up to a 9-fold increase in REs content in the lungs of rats that received RA or RAG for 12 days as compared to Control rats. The accumulation was most profound when RA was injected in DMSO and least when RAG was injected in cotton seed oil. The reason for the accumulation of REs in the lung is not clearly known.

Injections, Intraperitoneal

Rats

Esters - metabolism

Male

Rats, Sprague-Dawley

Vitamin A - metabolism

Animals

Tretinoin - metabolism

Lung - drug effects

Pulmonary Alveoli - metabolism

Pulmonary Alveoli - drug effects

Tretinoin - analogs & derivatives

Lung - metabolism

Pancreatic Elastase - pharmacology

Tretinoin - pharmacology

Details

Title: Subtitle: Elevation of retinyl ester level in the lungs of rats following repeated intraperitoneal injections of retinoic acid or retinoyl glucuronide
Creators: Arun B Barua - Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA. abarua@iastate.edu
Stephen E McGowan
Kristi D Ivanoff
Bhabesh C Goswami
James A Olson
Resource Type: Journal article
Publication Details: Pulmonary pharmacology & therapeutics, Vol.17(3), pp.113-119
Publisher: England
DOI: 10.1016/j.pupt.2003.12.001
PMID: 15123219
ISSN: 1094-5539
eISSN: 1522-9629
Grant note: DK 3973 / NIDDK NIH HHS R01 HL-62861 / NHLBI NIH HHS RR01 53430 / NCRR NIH HHS
Language: English
Date published: 2004
Academic Unit: International Programs; Internal Medicine
Record Identifier: 9983984519702771

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