Journal article
Elucidating cannabinoid biology in zebrafish (Danio rerio)
Gene, Vol.570(2), pp.168-179
10/10/2015
DOI: 10.1016/j.gene.2015.07.036
PMCID: PMC4943030
PMID: 26192460
Abstract
The number of annual cannabinoid users exceeds 100,000,000 globally and an estimated 9% of these individuals will suffer from dependency. Although exogenous cannabinoids, like those contained in marijuana, are known to exert their effects by disrupting the endocannabinoid system, a dearth of knowledge exists about the potential toxicological consequences on public health. Conversely, the endocannabinoid system represents a promising therapeutic target for a plethora of disorders because it functions to endogenously regulate a vast repertoire of physiological functions. Accordingly, the rapidly expanding field of cannabinoid biology has sought to leverage model organisms in order to provide both toxicological and therapeutic insights about altered endocannabinoid signaling. The primary goal of this manuscript is to review the existing field of cannabinoid research in the genetically tractable zebrafish model focusing on the cannabinoid receptor genes, cnr1 and cnr2, and the genes that produce enzymes for synthesis and degradation of the cognate ligands anandamide and 2-arachidonylglycerol. Consideration is also given to research that has studied the effects of exposure to exogenous phytocannabinoids and synthetic cannabinoids that are known to interact with cannabinoid receptors. These results are considered in the context of either endocannabinoid gene expression or endocannabinoid gene function, and are integrated with findings from rodent studies. This provides the framework for a discussion of how zebrafish may be leveraged in the future to provide novel toxicological and therapeutic insights in the field of cannabinoid biology, which has become increasingly significant given recent trends in cannabis legislation. (C) 2015 Elsevier B.V. All rights reserved.
Details
- Title: Subtitle
- Elucidating cannabinoid biology in zebrafish (Danio rerio)
- Creators
- Randall G. Krug - Mayo ClinicKarl J. Clark - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- Gene, Vol.570(2), pp.168-179
- DOI
- 10.1016/j.gene.2015.07.036
- PMID
- 26192460
- PMCID
- PMC4943030
- NLM abbreviation
- Gene
- ISSN
- 0378-1119
- eISSN
- 1879-0038
- Publisher
- Elsevier
- Number of pages
- 12
- Grant note
- Mayo Foundation for Medical Education and Research DA032194; RR15402-01 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Mayo Graduate School R01RR015402 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) R21DA032194 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission
- Language
- English
- Date published
- 10/10/2015
- Academic Unit
- Neurology
- Record Identifier
- 9985240987702771
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