Embracing systems toxicology at single-cell resolution

Qiang Zhang; W. Michael Caudle; Jingbo Pi; Sudin Bhattacharya; Melvin E. Andersen; Norbert E. Kaminski; Rory B. Conolly

doi:10.1016/j.cotox.2019.04.003

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Embracing systems toxicology at single-cell resolution

Journal article

Peer reviewed

Embracing systems toxicology at single-cell resolution

Qiang Zhang, W. Michael Caudle, Jingbo Pi, Sudin Bhattacharya, Melvin E. Andersen, Norbert E. Kaminski and Rory B. Conolly

Current opinion in toxicology, Vol.16, pp.49-57

08/2019

DOI: 10.1016/j.cotox.2019.04.003

PMCID: PMC6876623

PMID: 31768481

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https://www.ncbi.nlm.nih.gov/pmc/articles/6876623View

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Abstract

As systems biology expands its multi-omic spectrum to increasing resolutions, distinguishing cells based on single-cell profiles becomes feasible. Unlike traditional bulk assays that average cellular responses and blur the distinct identities of responsive cells, single-cell technologies enable sensitive detection of small cellular changes and precise identification of those cells perturbed by toxicants. Among the suite of omic technologies that continue to expand and become affordable, single-cell RNA sequencing is at the cutting edge and leading the way to transform systems toxicology. Single-cell systems toxicology can provide a wealth of information to elucidate cell-specific alterations and response trajectories, detect points of departure, and map and develop dynamical models of toxicity pathways.

Bulk assay

Computational toxicology

Machine learning

Single-cell RNA sequencing

Systems toxicology

Transcriptomics

Details

Title: Subtitle: Embracing systems toxicology at single-cell resolution
Creators: Qiang Zhang - Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA
W. Michael Caudle - Emory University
Jingbo Pi - China Medical University
Sudin Bhattacharya - Michigan State University
Melvin E. Andersen - Research Triangle Park Foundation
Norbert E. Kaminski - Michigan State University
Rory B. Conolly - Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Durham, North Carolina, USA.
Resource Type: Journal article
Publication Details: Current opinion in toxicology, Vol.16, pp.49-57
DOI: 10.1016/j.cotox.2019.04.003
PMID: 31768481
PMCID: PMC6876623
NLM abbreviation: Curr Opin Toxicol
ISSN: 2468-2020
eISSN: 2468-2020
Publisher: Elsevier B.V
Grant note: DOI: 10.13039/100000066, name: National Institute of Environmental Health Sciences Superfund Research, award: P42ES04911; name: National Institute of Environmental Health Sciences HERCULES, award: P30ES019776
Language: English
Date published: 08/2019
Academic Unit: Neurology
Record Identifier: 9984303027202771

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