Journal article
Embracing the Future of Clinical Trials in Radiotherapy: An NRG Oncology CIRO Technology Retreat Whitepaper on Pioneering Technologies and AI-Driven Solutions
International journal of radiation oncology, biology, physics, Vol.122(2), pp.443-457
06/2025
DOI: 10.1016/j.ijrobp.2025.01.006
PMCID: PMC12086052
PMID: 39848295
Abstract
This white paper examines the potential of pioneering technologies and artificial intelligence (AI)-driven solutions in advancing clinical trials involving radiotherapy. As the field of radiotherapy evolves, the integration of cutting-edge approaches such as radiopharmaceutical dosimetry, FLASH radiotherapy, image-guided radiation therapy (IGRT), and AI promises to improve treatment planning, patient care, and outcomes. Additionally, recent advancements in quantum science, linear energy transfer/relative biological effect (LET/RBE), and the combination of radiotherapy and immunotherapy create new avenues for innovation in clinical trials. The paper aims to provide an overview of these emerging technologies and discuss their challenges and opportunities in shaping the future of radiation oncology clinical trials. By synthesizing knowledge from experts across various disciplines, this white paper aims to present a foundation for the successful integration of these innovations into radiotherapy research and practice, ultimately enhancing patient outcomes and revolutionizing cancer care.This white paper examines the potential of pioneering technologies and artificial intelligence (AI)-driven solutions in advancing clinical trials involving radiotherapy. As the field of radiotherapy evolves, the integration of cutting-edge approaches such as radiopharmaceutical dosimetry, FLASH radiotherapy, image-guided radiation therapy (IGRT), and AI promises to improve treatment planning, patient care, and outcomes. Additionally, recent advancements in quantum science, linear energy transfer/relative biological effect (LET/RBE), and the combination of radiotherapy and immunotherapy create new avenues for innovation in clinical trials. The paper aims to provide an overview of these emerging technologies and discuss their challenges and opportunities in shaping the future of radiation oncology clinical trials. By synthesizing knowledge from experts across various disciplines, this white paper aims to present a foundation for the successful integration of these innovations into radiotherapy research and practice, ultimately enhancing patient outcomes and revolutionizing cancer care.
Details
- Title: Subtitle
- Embracing the Future of Clinical Trials in Radiotherapy: An NRG Oncology CIRO Technology Retreat Whitepaper on Pioneering Technologies and AI-Driven Solutions
- Creators
- Ying Xiao - University of PennsylvaniaStanley Benedict - University of California, DavisYunfeng Cui - Duke UniversityCarri Glide-Hurst - University of Wisconsin–MadisonTawfik Giaddui - Temple University HospitalStephen Graves - University of IowaXun Jia - Johns Hopkins UniversityStephen F Kry - The University of Texas MD Anderson Cancer CenterHeng Li - Johns Hopkins UniversityLiyong Lin - Emory UniversityMartha Matuszak - University of MichiganMark Newpower - University of Oklahoma Health Sciences CenterHarald Paganetti - Massachusetts General HospitalX Sharon Qi - University of California, Los AngelesEmilie Roncali - University of California, DavisYi Rong - Mayo Clinic in ArizonaGeorge Sgouros - Johns Hopkins UniversityCharles B Simone - New York Proton CenterJohn J Sunderland - University of IowaPaige A Taylor - The University of Texas MD Anderson Cancer CenterLeila Tchelebi - Northwell HealthMichael Weldon - The Ohio State UniversityJennifer W Zou - University of PennsylvaniaEvan J Wuthrick - Moffitt Cancer CenterMitchell Machtay - Penn State Milton S. Hershey Medical CenterQuynh-Thu Le - Stanford UniversityJeffrey C Buchsbaum - National Cancer Institute
- Resource Type
- Journal article
- Publication Details
- International journal of radiation oncology, biology, physics, Vol.122(2), pp.443-457
- DOI
- 10.1016/j.ijrobp.2025.01.006
- PMID
- 39848295
- PMCID
- PMC12086052
- NLM abbreviation
- Int J Radiat Oncol Biol Phys
- ISSN
- 1879-355X
- eISSN
- 1879-355X
- Publisher
- ELSEVIER SCIENCE INC
- Grant note
- UC Davis Comprehensive Cancer Center, National Clinical Trial Network (NCTN) U10 Program: ISBN 978-3-319-44827-5, U10CA180846
J.C.B., Y.C., X.J., H.L., M. Machtay, M. Matuszak, X.S.Q.,J.L.S., L.T., M.W., and E.J.W. have nothing to disclose. S.B. declares in thelast 36 months grants or contracts as Co-Investigator/U10CA180846 from UC Davis Comprehensive Cancer Center, National Clinical Trial Network (NCTN) U10 Program, Royalties or licenses as editor on ISBN 9781138198548 and ISBN 978-3-319-44827-5, support for attending meetings and/or travel as Editor (Therapy) of Medical Physics for the AAPM, leadership or fiduciary role in other board, society, committee, or advocacy group, paid or unpaid as a member of and BOD of Radiosurgery Society.
- Language
- English
- Electronic publication date
- 01/21/2025
- Date published
- 06/2025
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984775262802771
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