Embryonal Tumors of the Central Nervous System: An Update

Melissa M Blessing; Sanda Alexandrescu

doi:10.1016/j.path.2020.01.003

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Journal article

Embryonal Tumors of the Central Nervous System: An Update

Melissa M Blessing and Sanda Alexandrescu

Surgical pathology clinics, Vol.13(2), pp.235-247

06/2020

DOI: 10.1016/j.path.2020.01.003

PMID: 32389264

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Abstract

Embryonal tumors of the central nervous system (CNS) are rare, high-grade neoplasms predominantly affecting the pediatric population. Well-defined embryonal tumors include medulloblastoma, atypical teratoid/rhabdoid tumor, embryonal tumor with multilayered rosettes, C19MC-altered and embryonal tumor with multilayered rosettes, not otherwise specified, pineoblastoma, pituitary blastoma, CNS neuroblastoma, and ganglioneuroblastoma. Although their prognosis is nearly uniformly poor, the rapidly evolving understanding of their molecular biology contributes to diagnosis, prognosis, treatment, and clinical trial participation. Knowledge of current tumor stratification and diagnostic techniques will help pathologists guide care and preserve tissue for necessary or desired additional testing.

Central Nervous System Neoplasms - diagnosis

Central Nervous System Neoplasms - pathology

Central Nervous System Neoplasms - therapy

Cerebellar Neoplasms - diagnosis

Cerebellar Neoplasms - pathology

Cerebellar Neoplasms - therapy

Humans

Medulloblastoma - diagnosis

Medulloblastoma - pathology

Medulloblastoma - therapy

Neoplasms, Germ Cell and Embryonal - diagnosis

Neoplasms, Germ Cell and Embryonal - pathology

Neoplasms, Germ Cell and Embryonal - therapy

Prognosis

Rhabdoid Tumor - diagnosis

Rhabdoid Tumor - pathology

Rhabdoid Tumor - therapy

Teratoma - diagnosis

Teratoma - pathology

Teratoma - therapy

Details

Title: Subtitle: Embryonal Tumors of the Central Nervous System: An Update
Creators: Melissa M Blessing - Boston Children's Hospital
Sanda Alexandrescu - Boston Children's Hospital
Resource Type: Journal article
Publication Details: Surgical pathology clinics, Vol.13(2), pp.235-247
DOI: 10.1016/j.path.2020.01.003
PMID: 32389264
ISSN: 1875-9181
eISSN: 1875-9157
Language: English
Date published: 06/2020
Academic Unit: Pathology
Record Identifier: 9984755387902771

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