Journal article
Emergence of Nonobstructive Coronary Artery Disease A Woman's Problem and Need for Change in Definition on Angiography
Journal of the American College of Cardiology, Vol.66(17), pp.1918-1933
10/27/2015
DOI: 10.1016/j.jacc.2015.08.876
PMCID: PMC4618799
PMID: 26493665
Abstract
Recognition of ischemic heart disease (IHD) is often delayed or deferred in women. Thus, many at risk for adverse outcomes are not provided specific diagnostic, preventive, and/or treatment strategies. This lack of recognition is related to sex-specific IHD pathophysiology that differs from traditional models using data from men with flow-limiting coronary artery disease (CAD) obstructions. Symptomatic women are less likely to have obstructive CAD than men with similar symptoms, and tend to have coronary microvascular dysfunction, plaque erosion, and thrombus formation. Emerging data document that more extensive, nonobstructive CAD involvement, hypertension, and diabetes are associated with major adverse events similar to those with obstructive CAD. A central emerging paradigm is the concept of nonobstructive CAD as a cause of IHD and related adverse outcomes among women. This position paper summarizes currently available knowledge and gaps in that knowledge, and recommends management options that could be useful until additional evidence emerges. (C) 2015 by the American College of Cardiology Foundation.
Details
- Title: Subtitle
- Emergence of Nonobstructive Coronary Artery Disease A Woman's Problem and Need for Change in Definition on Angiography
- Creators
- Carl J. Pepine - University of FloridaKeith C. Ferdinand - Tulane UniversityLeslee J. Shaw - Emory UniversityKelly Ann Light-McGroary - University of IowaRashmee U. Shah - University of UtahMartha Gulati - The Ohio State UniversityClaire Duvernoy - Michigan MedicineMary Norine Walsh - St Vincent HospitalC. Noel Bairey Merz - Cedars-Sinai Smidt Heart InstituteACC CVD in Women Committee
- Resource Type
- Journal article
- Publication Details
- Journal of the American College of Cardiology, Vol.66(17), pp.1918-1933
- DOI
- 10.1016/j.jacc.2015.08.876
- PMID
- 26493665
- PMCID
- PMC4618799
- NLM abbreviation
- J Am Coll Cardiol
- ISSN
- 0735-1097
- eISSN
- 1558-3597
- Publisher
- Elsevier
- Number of pages
- 16
- Grant note
- UL1TR000124; UL1TR000064 / National Center for Advancing Translational Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) Pfizer Women's Guild of Cedars-Sinai Medical Center, Los Angeles MO1-RR00425 / GCRC grant from the National Center for Research Resources Medscape U0164829; U01 HL649141; U01 HL649241; K23HL105787; T32HL69751; R01 HL090957; 1R03AG032631 / National Institute on Aging; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) QMED, Inc., Laurence Harbor, NJ Constance Austin Women Heart Research Fellowship Linda Joy Pollin Women's Heart Health Program Erika Glazer Women's Heart Health Project, Cedars-Sinai Medical Center, Los Angeles, California
- Language
- English
- Date published
- 10/27/2015
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985034982802771
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