Journal article
Emerging Evidence on Coronary Heart Disease Screening in Kidney and Liver Transplantation Candidates: A Scientific Statement From the American Heart Association: Endorsed by the American Society of Transplantation
Circulation (New York, N.Y.), Vol.146(21), pp.E299-E324
11/22/2022
DOI: 10.1161/CIR.0000000000001104
PMCID: PMC10124159
PMID: 36252095
Abstract
Coronary heart disease is an important source of mortality and morbidity among kidney transplantation and liver transplantation candidates and recipients and is driven by traditional and nontraditional risk factors related to end-stage organ disease. In this scientific statement, we review evidence from the past decade related to coronary heart disease screening and management for kidney and liver transplantation candidates. Coronary heart disease screening in asymptomatic kidney and liver transplantation candidates has not been demonstrated to improve outcomes but is common in practice. Risk stratification algorithms based on the presence or absence of clinical risk factors and physical performance have been proposed, but a high proportion of candidates still meet criteria for screening tests. We suggest new approaches to pretransplantation evaluation grounded on the presence or absence of known coronary heart disease and cardiac symptoms and emphasize multidisciplinary engagement, including involvement of a dedicated cardiologist. Noninvasive functional screening methods such as stress echocardiography and myocardial perfusion scintigraphy have limited accuracy, and newer noninvasive modalities, especially cardiac computed tomography-based tests, are promising alternatives. Emerging evidence such as results of the 2020 International Study of Comparative Health Effectiveness With Medical and Invasive Approaches-Chronic Kidney Disease trial emphasizes the vital importance of guideline-directed medical therapy in managing diagnosed coronary heart disease and further questions the value of revascularization among asymptomatic kidney transplantation candidates. Optimizing strategies to disseminate and implement best practices for medical management in the broader end-stage organ disease population should be prioritized to improve cardiovascular outcomes in these populations.
Details
- Title: Subtitle
- Emerging Evidence on Coronary Heart Disease Screening in Kidney and Liver Transplantation Candidates: A Scientific Statement From the American Heart Association: Endorsed by the American Society of Transplantation
- Creators
- Xingxing S. ChengLisa B. VanWagnerSalvatore P. CostaDavid A. AxelrodSripal BangaloreSilas P. NormanCharles A. HerzogKrista L. LentineAmerican Heart Association Council on the Kidney in Cardiovascular Disease and Council on Cardiovascular Radiology and Intervention
- Resource Type
- Journal article
- Publication Details
- Circulation (New York, N.Y.), Vol.146(21), pp.E299-E324
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1161/CIR.0000000000001104
- PMID
- 36252095
- PMCID
- PMC10124159
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Number of pages
- 26
- Language
- English
- Date published
- 11/22/2022
- Academic Unit
- Surgery
- Record Identifier
- 9984322931102771
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