Journal article
Emerging Priorities for Microbiome Research
Frontiers in microbiology, Vol.11, pp.136-136
02/19/2020
DOI: 10.3389/fmicb.2020.00136
PMCID: PMC7042322
PMID: 32140140
Abstract
Microbiome research has increased dramatically in recent years, driven by advances in technology and significant reductions in the cost of analysis. Such research has unlocked a wealth of data, which has yielded tremendous insight into the nature of the microbial communities, including their interactions and effects, both within a host and in an external environment as part of an ecological community. Understanding the role of microbiota, including their dynamic interactions with their hosts and other microbes, can enable the engineering of new diagnostic techniques and interventional strategies that can be used in a diverse spectrum of fields, spanning from ecology and agriculture to medicine and from forensics to exobiology. From June 19–23 in 2017, the NIH and NSF jointly held an Innovation Lab on
Quantitative Approaches to Biomedical Data Science Challenges in our Understanding of the Microbiome
. This review is inspired by some of the topics that arose as priority areas from this unique, interactive workshop. The goal of this review is to summarize the Innovation Lab’s findings by introducing the reader to emerging challenges, exciting potential, and current directions in microbiome research. The review is broken into five key topic areas: (1) interactions between microbes and the human body, (2) evolution and ecology of microbes, including the role played by the environment and microbe-microbe interactions, (3) analytical and mathematical methods currently used in microbiome research, (4) leveraging knowledge of microbial composition and interactions to develop engineering solutions, and (5) interventional approaches and engineered microbiota that may be enabled by selectively altering microbial composition. As such, this review seeks to arm the reader with a broad understanding of the priorities and challenges in microbiome research today and provide inspiration for future investigation and multi-disciplinary collaboration.
Details
- Title: Subtitle
- Emerging Priorities for Microbiome Research
- Creators
- Chad M Cullen - School of Biomedical Engineering, Science and Health Systems, Drexel UniversityKawalpreet K Aneja - The School District of PhiladelphiaSinem Beyhan - Department of Infectious Diseases, J. Craig Venter InstituteClara E Cho - Department of Nutrition, Dietetics and Food Sciences, Utah State UniversityStephen Woloszynek - Ecological and Evolutionary Signal-processing and Informatics Laboratory (EESI), Electrical and Computer Engineering, Drexel UniversityMatteo Convertino - Nexus Group, Faculty of Information Science and Technology, Gi-CoRE Station for Big Data & Cybersecurity, Hokkaido UniversitySophie J McCoy - Department of Biological Science, Florida State UniversityYanyan Zhang - Department of Civil Engineering, New Mexico State UniversityMatthew Z Anderson - Department of Microbiology, The Ohio State UniversityDavid Alvarez-Ponce - Department of Biology, University of Nevada, RenoEkaterina Smirnova - Department of Biostatistics, Virginia Commonwealth UniversityLisa Karstens - Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science UniversityPieter C Dorrestein - Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San DiegoHongzhe Li - Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of PennsylvaniaAnanya Sen Gupta - Department of Electrical and Computer Engineering, The University of IowaKevin Cheung - Department of Dermatology, The University of IowaJennifer Gloeckner Powers - Department of Dermatology, The University of IowaZhengqiao Zhao - Ecological and Evolutionary Signal-processing and Informatics Laboratory (EESI), Electrical and Computer Engineering, Drexel UniversityGail L Rosen - School of Biomedical Engineering, Science and Health Systems, Drexel University
- Resource Type
- Journal article
- Publication Details
- Frontiers in microbiology, Vol.11, pp.136-136
- DOI
- 10.3389/fmicb.2020.00136
- PMID
- 32140140
- PMCID
- PMC7042322
- NLM abbreviation
- Front Microbiol
- ISSN
- 1664-302X
- eISSN
- 1664-302X
- Publisher
- Frontiers Media S.A
- Language
- English
- Date published
- 02/19/2020
- Academic Unit
- Dermatology; Electrical and Computer Engineering
- Record Identifier
- 9984066334402771
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