Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases

Juan Shi; Shuhong Chi; Jing Xue; Jiali Yang; Feng Li; Xiaoming Liu

doi:10.1155/2016/9392132

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Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases

Journal article

Open access

Peer reviewed

Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases

Juan Shi, Shuhong Chi, Jing Xue, Jiali Yang, Feng Li and Xiaoming Liu

Journal of immunology research, Vol.2016, 9392132

2016

DOI: 10.1155/2016/9392132

PMCID: PMC4826689

PMID: 27110577

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Abstract

The Wnt signaling pathway plays a key role in many biological aspects, such as cellular proliferation, tissue regeneration, embryonic development, and other systemic effects. Under a physiological condition, it is tightly controlled at different layers and arrays, and a dysregulated activation of this signaling has been implicated into the pathogenesis of various human disorders, including autoimmune diseases. Despite the fact that therapeutic interventions are available for ameliorating disease manifestations, there is no curative therapy currently available for autoimmune disorders. Increasing lines of evidence have suggested a crucial role of Wnt signaling during the pathogenesis of many autoimmune diseases; in addition, some of microRNAs (miRNAs), a class of small, noncoding RNA molecules capable of transcriptionally regulating gene expression, have also recently been demonstrated to possess both physiological and pathological roles in autoimmune diseases by regulating the Wnt signaling pathway. This review summarizes currently our understanding of the pathogenic roles of Wnt signaling in several major autoimmune disorders and miRNAs, those targeting Wnt signaling in autoimmune diseases, with a focus on the implication of the Wnt signaling as potential biomarkers and therapeutic targets in immune diseases, as well as miRNA-mediated regulation of Wnt signaling activation in the development of autoimmune diseases.

Axin Protein - genetics

Humans

Inflammatory Bowel Diseases - immunology

Wnt Signaling Pathway - immunology

Scleroderma, Systemic - pathology

Glycogen Synthase Kinase 3 beta

Glycogen Synthase Kinase 3 - immunology

Spondylitis, Ankylosing - immunology

beta Catenin - immunology

Wnt Proteins - genetics

Axin Protein - immunology

Inflammatory Bowel Diseases - pathology

Inflammatory Bowel Diseases - genetics

Lupus Erythematosus, Systemic - immunology

Disease Models, Animal

Spondylitis, Ankylosing - genetics

Gene Expression Regulation

Scleroderma, Systemic - genetics

Scleroderma, Systemic - immunology

MicroRNAs - immunology

beta Catenin - genetics

Wnt Proteins - immunology

Animals

Glycogen Synthase Kinase 3 - genetics

Lupus Erythematosus, Systemic - genetics

MicroRNAs - genetics

Lupus Erythematosus, Systemic - pathology

Spondylitis, Ankylosing - pathology

Details

Title: Subtitle: Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases
Creators: Juan Shi - Center of Laboratory Medicine, The General Hospital of Ningxia Medical University, Yinchuan 750004, China
Shuhong Chi - Department of Rheumatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, China
Jing Xue - Key Laboratory of the Ministry of Education for the Conservation and Utilization of Special Biological Resources of Western China, Ningxia University, Yinchuan, Ningxia 750021, China
Jiali Yang - Center of Laboratory Medicine, The General Hospital of Ningxia Medical University, Yinchuan 750004, China
Feng Li - Center of Laboratory Medicine, The General Hospital of Ningxia Medical University, Yinchuan 750004, China
Xiaoming Liu - Key Laboratory of the Ministry of Education for the Conservation and Utilization of Special Biological Resources of Western China, Ningxia University, Yinchuan, Ningxia 750021, China; Institute of Human Stem Cell Research at the General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China
Resource Type: Journal article
Publication Details: Journal of immunology research, Vol.2016, 9392132
DOI: 10.1155/2016/9392132
PMID: 27110577
PMCID: PMC4826689
NLM abbreviation: J Immunol Res
ISSN: 2314-8861
eISSN: 2314-7156
Publisher: Egypt
Grant note: DOI: 10.13039/501100004772, name: Natural Science Foundation of Ningxia Province, award: NZ1213, 2009
Language: English
Date published: 2016
Academic Unit: Anatomy and Cell Biology
Record Identifier: 9984025317602771

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