Emerging Roles of Estrogen-Related Receptors in the Brain: Potential Interactions with Estrogen Signaling

Kenji Saito; Huxing Cui

doi:10.3390/ijms19041091

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Emerging Roles of Estrogen-Related Receptors in the Brain: Potential Interactions with Estrogen Signaling

Journal article

Open access

Peer reviewed

Emerging Roles of Estrogen-Related Receptors in the Brain: Potential Interactions with Estrogen Signaling

Kenji Saito and Huxing Cui

International journal of molecular sciences, Vol.19(4), p.1091

04/05/2018

DOI: 10.3390/ijms19041091

PMCID: PMC5979530

PMID: 29621182

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Abstract

In addition to their well-known role in the female reproductive system, estrogens can act in the brain to regulate a wide range of behaviors and physiological functions in both sexes. Over the past few decades, genetically modified animal models have greatly increased our knowledge about the roles of estrogen receptor (ER) signaling in the brain in behavioral and physiological regulations. However, less attention has been paid to the estrogen-related receptors (ERRs), the members of orphan nuclear receptors whose sequences are homologous to ERs but lack estrogen-binding ability. While endogenous ligands of ERRs remain to be determined, they seemingly share transcriptional targets with ERs and their expression can be directly regulated by ERs through the estrogen-response element embedded within the regulatory region of the genes encoding ERRs. Despite the broad expression of ERRs in the brain, we have just begun to understand the fundamental roles they play at molecular, cellular, and circuit levels. Here, we review recent research advancement in understanding the roles of ERs and ERRs in the brain, with particular emphasis on ERRs, and discuss possible cross-talk between ERs and ERRs in behavioral and physiological regulations.

estrogen

estrogen receptor

mitochondria

Review

estrogen-related receptors

brain

central nervous system

Details

Title: Subtitle: Emerging Roles of Estrogen-Related Receptors in the Brain: Potential Interactions with Estrogen Signaling
Creators: Kenji Saito - Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Huxing Cui - Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: International journal of molecular sciences, Vol.19(4), p.1091
DOI: 10.3390/ijms19041091
PMID: 29621182
PMCID: PMC5979530
NLM abbreviation: Int J Mol Sci
ISSN: 1661-6596
eISSN: 1422-0067
Publisher: MDPI
Language: English
Date published: 04/05/2018
Academic Unit: Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology
Record Identifier: 9984040355702771

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