Journal article
Emerging approaches to polypharmacy among older adults
Nature aging, Vol.1(4), pp.347-356
03/22/2021
DOI: 10.1038/s43587-021-00045-3
Abstract
Polypharmacy is a major health issue for older adults. Entangled with several geriatric syndromes, including frailty, falls and cognitive decline, research focused on polypharmacy has been challenged by heterogeneity in its definition, confounding by comorbidities and limited prospective data. In this Review, we discuss varying definitions for polypharmacy and highlight the need for a uniform definition for future studies. We critically appraise strategies for reducing medication prescriptions and implementing deprescribing as a mechanism to reduce the potential harmful effects of polypharmacy. As we look to the future, we assess the role of novel analytics and high-throughput technology, including multiomics profiling, to advance research in polypharmacy and the development of new strategies for risk stratification in the age of precision medicine.
Details
- Title: Subtitle
- Emerging approaches to polypharmacy among older adults
- Creators
- Raaj S. Mehta - Massachusetts General HospitalBharati D. Kochar - Massachusetts General HospitalKorey Kennelty - University of IowaMichael E. Ernst - University of IowaAndrew T. Chan - Massachusetts General Hospital
- Resource Type
- Journal article
- Publication Details
- Nature aging, Vol.1(4), pp.347-356
- DOI
- 10.1038/s43587-021-00045-3
- ISSN
- 2662-8465
- eISSN
- 2662-8465
- Grant note
- DOI: 10.13039/100000002, name: U.S. Department of Health & Human Services | National Institutes of Health, award: RF1 AG067744, U19 AG062682, R35 CA253185, U19 AG062682, RF1 AG067744
- Language
- English
- Date published
- 03/22/2021
- Academic Unit
- Family and Community Medicine; Pharmacy Practice and Science; Injury Prevention Research Center
- Record Identifier
- 9984297456102771
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