Emerging local delivery strategies to enhance bone regeneration

Satheesh Elangovan; Praveen Gajendrareddy; Sriram Ravindran; Aliasger K Salem

doi:10.1088/1748-605X/aba446

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Emerging local delivery strategies to enhance bone regeneration

Journal article

Peer reviewed

Emerging local delivery strategies to enhance bone regeneration

Satheesh Elangovan, Praveen Gajendrareddy, Sriram Ravindran and Aliasger K Salem

Biomedical materials (Bristol), Vol.15(6), pp.062001-062001/15

11/21/2020

DOI: 10.1088/1748-605X/aba446

PMCID: PMC10148649

PMID: 32647095

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10148649/pdf/nihms-1891134.pdfView

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Abstract

In orthopedics and dentistry there is an increasing need for novel biomaterials and clinical strategies to achieve predictable bone regeneration. These novel molecular strategies have the potential to eliminate the limitations of currently available approaches. Specifically, they have the potential to reduce or eliminate the need to harvest autogenous bone, and the overall complexity of the clinical procedures. In this review, emerging tissue engineering strategies that have been, or are currently being, developed based on the current understanding of bone biology, development and wound healing will be discussed. In particular, protein/peptide based approaches, DNA/RNA therapeutics, cell therapy, and the use of exosomes will be briefly covered. The review ends with a summary of the current status of these approaches, their clinical translational potentials and their challenges.

Animals

Biocompatible Materials - chemistry

Bone and Bones

Bone Regeneration

DNA - metabolism

Exosomes - metabolism

Genetic Therapy

Humans

Lipids - chemistry

Orthopedics - methods

Orthopedics - trends

Proteins - chemistry

Regeneration

RNA - metabolism

Tissue Engineering - methods

Tissue Scaffolds

Translational Research, Biomedical - methods

Translational Research, Biomedical - trends

Wound Healing

Details

Title: Subtitle: Emerging local delivery strategies to enhance bone regeneration
Creators: Satheesh Elangovan - Department of Periodontics, The University of Iowa College of Dentistry, Iowa City, IA 52242, United States of America
Praveen Gajendrareddy - Department of Periodontics, The University of Illinois at Chicago College of Dentistry, Chicago, IL 60612, United States of America
Sriram Ravindran - Department of Oral Biology, The University of Illinois at Chicago College of Dentistry, Chicago, IL 60612, United States of America
Aliasger K Salem - Department of Pharmaceutical Sciences and Experimental Therapeutics, The University of Iowa College of Pharmacy, Iowa City, IA 52242, United States of America
Resource Type: Journal article
Publication Details: Biomedical materials (Bristol), Vol.15(6), pp.062001-062001/15
DOI: 10.1088/1748-605X/aba446
PMID: 32647095
PMCID: PMC10148649
NLM abbreviation: Biomed Mater
ISSN: 1748-6041
eISSN: 1748-605X
Grant note: P30 ES005605 / NIEHS NIH HHS
Language: English
Date published: 11/21/2020
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering; Periodontics
Record Identifier: 9984216592502771

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