Emerging potential benefits of modulating NAD + metabolism in cardiovascular disease

Daniel S Matasic; Charles Brenner; Barry London

doi:10.1152/ajpheart.00409.2017

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Emerging potential benefits of modulating NAD + metabolism in cardiovascular disease

Journal article

Open access

Peer reviewed

Emerging potential benefits of modulating NAD + metabolism in cardiovascular disease

Daniel S Matasic, Charles Brenner and Barry London

American journal of physiology. Heart and circulatory physiology, Vol.314(4), pp.H839-H852

04/01/2018

DOI: 10.1152/ajpheart.00409.2017

PMCID: PMC5966770

PMID: 29351465

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Abstract

Nicotinamide adenine dinucleotide (NAD ) and related metabolites are central mediators of fuel oxidation and bioenergetics within cardiomyocytes. Additionally, NAD is required for the activity of multifunctional enzymes, including sirtuins and poly(ADP-ribose) polymerases that regulate posttranslational modifications, DNA damage responses, and Ca signaling. Recent research has indicated that NAD participates in a multitude of processes dysregulated in cardiovascular diseases. Therefore, supplementation of NAD precursors, including nicotinamide riboside that boosts or repletes the NAD metabolome, may be cardioprotective. This review examines the molecular physiology and preclinical data with respect to NAD precursors in heart failure-related cardiac remodeling, ischemic-reperfusion injury, and arrhythmias. In addition, alternative NAD -boosting strategies and potential systemic effects of NAD supplementation with implications on cardiovascular health and disease are surveyed.

Cardiovascular Diseases - physiopathology

NAD - therapeutic use

Cardiovascular Diseases - metabolism

Oxidation-Reduction

Cardiovascular Diseases - drug therapy

Humans

NAD - adverse effects

Cardiovascular Diseases - pathology

Cardiovascular Agents - therapeutic use

Myocytes, Cardiac - pathology

Animals

Myocytes, Cardiac - drug effects

Signal Transduction - drug effects

Myocytes, Cardiac - metabolism

Dietary Supplements - adverse effects

Cardiovascular Agents - adverse effects

Energy Metabolism - drug effects

NAD - metabolism

Details

Title: Subtitle: Emerging potential benefits of modulating NAD + metabolism in cardiovascular disease
Creators: Daniel S Matasic - Abboud Cardiovascular Research Center, University of Iowa , Iowa City, Iowa
Charles Brenner - Department of Biochemistry, Carver College of Medicine, University of Iowa , Iowa City, Iowa
Barry London - Abboud Cardiovascular Research Center, University of Iowa , Iowa City, Iowa
Resource Type: Journal article
Publication Details: American journal of physiology. Heart and circulatory physiology, Vol.314(4), pp.H839-H852
DOI: 10.1152/ajpheart.00409.2017
PMID: 29351465
PMCID: PMC5966770
NLM abbreviation: Am J Physiol Heart Circ Physiol
ISSN: 1522-1539
eISSN: 1522-1539
Publisher: United States
Grant note: T32 GM007337 / NIGMS NIH HHS R01 HL115955 / NHLBI NIH HHS
Language: English
Date published: 04/01/2018
Academic Unit: Molecular Physiology and Biophysics; Biochemistry and Molecular Biology; Internal Medicine
Record Identifier: 9983788429402771

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