Emestrins: Anti-Cryptococcus Epipolythiodioxopiperazines from Podospora australis

Yan Li; Qun Yue; Nicole M Krausert; Zhiqiang An; James B Gloer; Gerald F Bills

doi:10.1021/acs.jnatprod.6b00498

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Emestrins: Anti-Cryptococcus Epipolythiodioxopiperazines from Podospora australis

Journal article

Peer reviewed

Emestrins: Anti-Cryptococcus Epipolythiodioxopiperazines from Podospora australis

Yan Li, Qun Yue, Nicole M Krausert, Zhiqiang An, James B Gloer and Gerald F Bills

Journal of natural products (Washington, D.C.), Vol.79(9), pp.2357-2363

09/23/2016

DOI: 10.1021/acs.jnatprod.6b00498

PMID: 27557418

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Abstract

Eleven emestrin-type epipolythiodioxopiperazines, including four new compounds, emestrins H-K (1-4), were isolated from the crude extracts of two strains of the coprophilous fungus Podospora australis. The structures of 1-4 were established primarily by analysis of NMR data, and the absolute configuration of C-6 in 1 was independently assigned using the modified Mosher method. Four of the known emestrins obtained (emestrins C-E and MPC1001C) were found to selectively inhibit the growth of Cryptococcus neoformans. These results also represent the first report of chemistry from any strain of P. australis.

Antifungal Agents - pharmacology

Podospora - chemistry

Antifungal Agents - chemistry

Piperazines - chemistry

Piperazines - isolation & purification

Piperazines - pharmacology

Cryptococcus neoformans - drug effects

Antifungal Agents - isolation & purification

Microbial Sensitivity Tests

Animals

Horses

Nuclear Magnetic Resonance, Biomolecular

Molecular Structure

Defecation

Details

Title: Subtitle: Emestrins: Anti-Cryptococcus Epipolythiodioxopiperazines from Podospora australis
Creators: Yan Li - Texas Therapeutic Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston , Houston, Texas 77054, United States
Qun Yue - Texas Therapeutic Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston , Houston, Texas 77054, United States
Nicole M Krausert - Department of Chemistry, University of Iowa , Iowa City, Iowa 52242, United States
Zhiqiang An - Texas Therapeutic Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston , Houston, Texas 77054, United States
James B Gloer - Department of Chemistry, University of Iowa , Iowa City, Iowa 52242, United States
Gerald F Bills - Texas Therapeutic Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston , Houston, Texas 77054, United States
Resource Type: Journal article
Publication Details: Journal of natural products (Washington, D.C.), Vol.79(9), pp.2357-2363
DOI: 10.1021/acs.jnatprod.6b00498
PMID: 27557418
NLM abbreviation: J Nat Prod
ISSN: 0163-3864
eISSN: 1520-6025
Publisher: United States
Grant note: P30 CA016672 / NCI NIH HHS
Language: English
Date published: 09/23/2016
Academic Unit: Chemistry
Record Identifier: 9983985969302771

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