Emotional Modulation of Learning and Memory: Pharmacological Implications

Ryan T LaLumiere; James L McGaugh; Christa K McIntyre

doi:10.1124/pr.116.013474

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Emotional Modulation of Learning and Memory: Pharmacological Implications

Journal article

Open access

Peer reviewed

Emotional Modulation of Learning and Memory: Pharmacological Implications

Ryan T LaLumiere, James L McGaugh and Christa K McIntyre

Pharmacological reviews, Vol.69(3), pp.236-255

07/2017

DOI: 10.1124/pr.116.013474

PMCID: PMC5438110

PMID: 28420719

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Abstract

Memory consolidation involves the process by which newly acquired information becomes stored in a long-lasting fashion. Evidence acquired over the past several decades, especially from studies using post-training drug administration, indicates that emotional arousal during the consolidation period influences and enhances the strength of the memory and that multiple different chemical signaling systems participate in this process. The mechanisms underlying the emotional influences on memory involve the release of stress hormones and activation of the basolateral amygdala, which work together to modulate memory consolidation. Moreover, work suggests that this amygdala-based memory modulation occurs with numerous types of learning and involves interactions with many different brain regions to alter consolidation. Additionally, studies suggest that emotional arousal and amygdala activity in particular influence synaptic plasticity and associated proteins in downstream brain regions. This review considers the historical understanding for memory modulation and cellular consolidation processes and examines several research areas currently using this foundational knowledge to develop therapeutic treatments.

Emotions - physiology

Memory - drug effects

Learning - drug effects

Humans

Neuronal Plasticity - drug effects

Brain - physiology

Emotions - drug effects

Arousal - drug effects

Brain - drug effects

Learning - physiology

Arousal - physiology

Animals

Neuronal Plasticity - physiology

Memory - physiology

Details

Title: Subtitle: Emotional Modulation of Learning and Memory: Pharmacological Implications
Creators: Ryan T LaLumiere - Department of Psychological and Brain Sciences and Interdisciplinary Neuroscience Program, University of Iowa, Iowa City, Iowa (R.T.L.); Department of Neurobiology and Behavior, University of California, Irvine, California (J.L.M.); and School of Behavioral and Brain Sciences, University of Texas-Dallas, Richardson, Texas (C.K.M.) ryan-lalumiere@uiowa.edu
James L McGaugh - Department of Psychological and Brain Sciences and Interdisciplinary Neuroscience Program, University of Iowa, Iowa City, Iowa (R.T.L.); Department of Neurobiology and Behavior, University of California, Irvine, California (J.L.M.); and School of Behavioral and Brain Sciences, University of Texas-Dallas, Richardson, Texas (C.K.M.)
Christa K McIntyre - Department of Psychological and Brain Sciences and Interdisciplinary Neuroscience Program, University of Iowa, Iowa City, Iowa (R.T.L.); Department of Neurobiology and Behavior, University of California, Irvine, California (J.L.M.); and School of Behavioral and Brain Sciences, University of Texas-Dallas, Richardson, Texas (C.K.M.)
Resource Type: Journal article
Publication Details: Pharmacological reviews, Vol.69(3), pp.236-255
DOI: 10.1124/pr.116.013474
PMID: 28420719
PMCID: PMC5438110
NLM abbreviation: Pharmacol Rev
ISSN: 1521-0081
eISSN: 1521-0081
Publisher: United States
Grant note: R43 MH105014 / NIMH NIH HHS R01 MH104384 / NIMH NIH HHS R01 DA037216 / NIDA NIH HHS R15 MH099655 / NIMH NIH HHS R01 DA034684 / NIDA NIH HHS
Language: English
Date published: 07/2017
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984002356602771

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