Emotional and Motivational Changes After Bilateral Lesions of the Globus Pallidus

Lavanya Vijayaraghavan; Jatin G Vaidya; Clare T Humphreys; Leigh J Beglinger; Sergio Paradiso

doi:10.1037/0894-4105.22.3.412

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Emotional and Motivational Changes After Bilateral Lesions of the Globus Pallidus

Journal article

Peer reviewed

Emotional and Motivational Changes After Bilateral Lesions of the Globus Pallidus

Lavanya Vijayaraghavan, Jatin G Vaidya, Clare T Humphreys, Leigh J Beglinger and Sergio Paradiso

Neuropsychology, Vol.22(3), pp.412-418

05/2008

DOI: 10.1037/0894-4105.22.3.412

PMID: 18444719

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Abstract

This study investigated motivational changes in a 44 year-old man (PJ) who developed considerable reduction in spontaneous activity and speech, flat affect, social withdrawal, loss of interest, inability to "feel," and lack of concern regarding his medical condition after bilateral, focal, anoxic lesions of the globus pallidus. PJ and 30 male controls performed a task designed to parse hedonic evaluation, or liking, from incentive motivation, or wanting. Affective stimuli were presented on a computer screen and subjects controlled viewing time by pressing keys. PJ's liking and wanting of unpleasant stimuli was similar to that of controls. In response to pleasant stimuli, PJ showed normal ratings of wanting and hedonic appreciation, but significantly reduced viewing time or made no responses. Active withdrawal from liked stimuli could constitute the basic mechanism underlying poor motivation and social withdrawal associated with globus pallidus damage.

incentive motivation

emotion

athymhormia

hedonic evaluation

alexithymia

globus pallidus

apathy

Details

Title: Subtitle: Emotional and Motivational Changes After Bilateral Lesions of the Globus Pallidus
Creators: Lavanya Vijayaraghavan
Jatin G Vaidya - Department of Psychiatry, University of Iowa Hospitals & Clinics
Clare T Humphreys - Department of Psychiatry, University of Iowa Hospitals & Clinics
Leigh J Beglinger - Department of Psychiatry, University of Iowa Hospitals & Clinics
Sergio Paradiso
Resource Type: Journal article
Publication Details: Neuropsychology, Vol.22(3), pp.412-418
DOI: 10.1037/0894-4105.22.3.412
PMID: 18444719
NLM abbreviation: Neuropsychology
ISSN: 0894-4105
eISSN: 1931-1559
Publisher: American Psychological Association
Grant note: name: Edward J. Mallinckrodt, Jr., Foundation; DOI: 10.13039/100000002, name: National Institutes of Health
Language: English
Date published: 05/2008
Academic Unit: Psychiatry; Iowa Neuroscience Institute; University College Courses
Record Identifier: 9984004184202771

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