Emotional blunting following left basal ganglia stroke: the role of depression and fronto-limbic functional alterations

Sergio Paradiso; Katharine Ostedgaard; Jatin Vaidya; Laura Boles Ponto; Robert Robinson

doi:10.1016/j.pscychresns.2012.05.008

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Emotional blunting following left basal ganglia stroke: the role of depression and fronto-limbic functional alterations

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Emotional blunting following left basal ganglia stroke: the role of depression and fronto-limbic functional alterations

Sergio Paradiso, Katharine Ostedgaard, Jatin Vaidya, Laura Boles Ponto and Robert Robinson

Psychiatry research, Vol.211(2), pp.148-159

02/28/2013

DOI: 10.1016/j.pscychresns.2012.05.008

PMCID: PMC4019790

PMID: 23176970

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http://doi.org/10.1016/j.pscychresns.2012.05.008View

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Abstract

Disorders of the basal ganglia (BG) alter perception and experience of emotions. Left hemisphere BG (LBG) stroke is also associated with depression. The interplay between depression and alterations in emotional processing following LBG stroke was examined. Evoked affective responses to emotion-laden pictorial stimuli were compared among LBG stroke and healthy participants and participants with stroke damage in brain regions not including the LBG selected to equate depression severity (measured using the Hamilton Depression Scale) with LBG damage participants. Brain activity {[O(15)]water positron emission tomography, PET} was measured in LBG stroke relative to healthy participants to identify changes in regions associated with emotion processing and depression. LBG stroke subjects reported less intense emotions compared with healthy, but not stroke comparison participants. Depression negatively correlated with emotional experience for positive and negative emotions. In response to positive stimuli, LBG subjects exhibited higher activity in amygdala, anterior cingulate, dorsal prefrontal cortex, and insula compared to healthy volunteers. In response to negative stimuli, LBG subjects demonstrated lower activity in right frontal-polar region and fusiform gyrus. Higher baseline activity in amygdala and ventral and mesial prefrontal cortex and lower activity in left dorsal lateral prefrontal cortex were associated with higher depression scores. LBG stroke led to blunted emotions, and brain activity alterations accounting for reduced affective experience, awareness and depression. Depression and fronto-limbic activity changes may contribute to emotional blunting following LBG stroke.

Basal Ganglia - diagnostic imaging

Depression - physiopathology

Stroke - diagnostic imaging

Basal Ganglia - physiopathology

Humans

Stroke - complications

Male

Stroke - physiopathology

Case-Control Studies

Affective Symptoms - complications

Neuropsychological Tests

Psychiatric Status Rating Scales

Functional Neuroimaging

Radionuclide Imaging

Affective Symptoms - diagnostic imaging

Depression - complications

Female

Aged

Functional Laterality - physiology

Affective Symptoms - physiopathology

Depression - diagnostic imaging

Details

Title: Subtitle: Emotional blunting following left basal ganglia stroke: the role of depression and fronto-limbic functional alterations
Creators: Sergio Paradiso - Department of Psychiatry, The University of Iowa-Carver College of Medicine, Iowa City, IA, USA. sergio-paradiso@uiowa.edu
Katharine Ostedgaard
Jatin Vaidya
Laura Boles Ponto
Robert Robinson
Resource Type: Journal article
Publication Details: Psychiatry research, Vol.211(2), pp.148-159
DOI: 10.1016/j.pscychresns.2012.05.008
PMID: 23176970
PMCID: PMC4019790
NLM abbreviation: Psychiatry Res Neuroimaging
ISSN: 0925-4927
eISSN: 1872-7123
Publisher: Ireland
Grant note: MH-00163 / NIMH NIH HHS 7R01CA-74959-04 / NCI NIH HHS R01DA-10551 / NIDA NIH HHS R01 DA010551 / NIDA NIH HHS R01 MH060990 / NIMH NIH HHS P50DC-03189 / NIDCD NIH HHS 1R01MH-60990-01 / NIMH NIH HHS K02 MH000163 / NIMH NIH HHS MH-52879 / NIMH NIH HHS K23AG027837 / NIA NIH HHS K23 AG027837 / NIA NIH HHS R01 MH052879 / NIMH NIH HHS
Language: English
Date published: 02/28/2013
Academic Unit: Radiology; Psychiatry; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; University College Courses
Record Identifier: 9984051984802771

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