Journal article
Enantioselective Synthesis of (+)-Hippolide J and Reevaluation of Antifungal Activity
Organic letters, Vol.22(19), pp.7743-7746
10/02/2020
DOI: 10.1021/acs.orglett.0c02979
PMCID: PMC7824975
PMID: 32969231
Abstract
A synthesis of the reported antifungal agent (+)-hippolide J is presented. The rapid assembly of the natural product was enabled through implementation of an enantioselective isomerization/[2 + 2]-cycloaddition sequence. Due to the simplicity of the route, >100 mg of the natural product were prepared in a single pass. Anitfungal assays of hippolide J, however, confirmed that it showed no activity against several fungal strains, contrary to the isolation report.
Details
- Title: Subtitle
- Enantioselective Synthesis of (+)-Hippolide J and Reevaluation of Antifungal Activity
- Creators
- Renyu Guo - Indiana UniversitySarah R. Beattie - Roy J. and Lucille A. Carver College of MedicineDamian J. Krysan - Roy J. and Lucille A. Carver College of MedicineM. Kevin Brown - Indiana University
- Resource Type
- Journal article
- Publication Details
- Organic letters, Vol.22(19), pp.7743-7746
- DOI
- 10.1021/acs.orglett.0c02979
- PMID
- 32969231
- PMCID
- PMC7824975
- NLM abbreviation
- Org Lett
- ISSN
- 1523-7060
- eISSN
- 1523-7052
- Publisher
- Amer Chemical Soc
- Number of pages
- 4
- Grant note
- CHE1726633 / NSF; National Science Foundation (NSF) R01GM110131; R35GM131755; F32AI1-45160 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Indiana University Vice Provost for Research through the Research Equipment Fund Indiana University
- Language
- English
- Date published
- 10/02/2020
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984297331202771
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